转移器官嗜性：重新定义亲和土壤。
Metastasis Organotropism: Redefining the Congenial Soil.
机构信息
Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
出版信息
Dev Cell. 2019 May 6;49(3):375-391. doi: 10.1016/j.devcel.2019.04.012.
Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as "organotropism." Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism.
转移是癌症进展最具破坏性的阶段，也是导致大多数癌症相关死亡的主要原因。临床观察表明，大多数癌症会转移到特定的器官，这一过程被称为“器官趋向性”。阐明潜在的机制可能有助于确定靶点和治疗策略，使患者受益。本文综述了肿瘤内在特性及其与宿主器官独特特征相互作用的最新研究进展，这些共同决定了器官特异性转移行为。与代谢变化、靶器官免疫图谱以及上皮-间充质转化的变化相关的新见解为转移器官趋向性的未来研究开辟了途径。
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