芦丁在男性不育症中的治疗潜力：一篇综述。

Therapeutic potential of rutin in male infertility: A mini review.

作者信息

Rotimi Damilare Emmanuel, Elebiyo Tobiloba Christiana, Ojo Oluwafemi Adeleke

机构信息

SDG 03 Group-Good Health & Well-being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria; Department of Biochemistry, Landmark University, Omu-Aran 251101, Kwara State, Nigeria.

Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo 232101, Osun State, Nigeria.

出版信息

J Integr Med. 2023 Mar;21(2):130-135. doi: 10.1016/j.joim.2023.01.004. Epub 2023 Jan 20.

DOI:10.1016/j.joim.2023.01.004

PMID:36717303

Abstract

Male infertility has become a problem worldwide, and recent research has emphasized the development of more effective therapy options. Among natural compounds, rutin has been widely studied for its potential to treat dysfunction related to male infertility, including a reduction in sperm quality, spermatogenesis disruption and structural disruption in the testis. A thorough review of scientific literature published in several databases, including Google Scholar, PubMed/MEDLINE and Scopus, was used to synthesize the present state of research on the role of rutin in male reproductive health. Rutin has been shown to possess antiapoptotic, antioxidant and anti-inflammatory activities, among others, which are crucial in the management of male infertility. Numerous investigations have shown that rutin protects against male infertility and have explored the underlying mechanisms involved. The present review, therefore, assesses the therapeutic mechanisms involved in male infertility treatment using rutin. Rutin was able to mitigate the induced oxidative stress, apoptosis, inflammation, and related physiological processes that can cause testicular dysfunction. Please cite this article as: Rotimi DE, Elebiyo TC, Ojo OA. Therapeutic potential of rutin in male infertility: A mini review. J Integr Med. 2023; 21(2): 130-135.

摘要

男性不育已成为一个全球性问题，最近的研究强调了开发更有效治疗方案的重要性。在天然化合物中，芦丁因其治疗与男性不育相关功能障碍的潜力而受到广泛研究，这些功能障碍包括精子质量下降、精子发生破坏以及睾丸结构破坏。通过全面回顾在多个数据库（包括谷歌学术、PubMed/MEDLINE和Scopus）中发表的科学文献，来综合阐述芦丁在男性生殖健康中作用的研究现状。研究表明，芦丁具有抗凋亡、抗氧化和抗炎等活性，这些活性在男性不育的治疗中至关重要。大量研究表明芦丁可预防男性不育，并对其中涉及的潜在机制进行了探索。因此，本综述评估了芦丁治疗男性不育所涉及的治疗机制。芦丁能够减轻诱导的氧化应激、细胞凋亡、炎症以及可能导致睾丸功能障碍的相关生理过程。请将本文引用为：Rotimi DE, Elebiyo TC, Ojo OA. 芦丁在男性不育中的治疗潜力：一篇综述。《整合医学杂志》。2023；21(2)：130 - 135。