Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, Belgium.
Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, 3000, Leuven, Belgium; Department of Internal Medicine and Medical Specialties, University of Genoa, IT-16132, Genoa, Italy.
Breast. 2023 Jun;69:476-480. doi: 10.1016/j.breast.2023.01.010. Epub 2023 Jan 25.
Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer, mainly characterized using primary tumor samples. Here, using public datasets, we compared the genomic alterations in primary and metastatic samples from patients with metastatic IBC versus patients with metastatic non-IBC. We observed a higher frequency of AURKA amplification in IBC. We further showed that AURKA amplification was associated with increased AURKA mRNA expression, which we demonstrated was higher in IBC. Finally, higher protein expression of AURKA was associated with worse prognosis in patients with IBC. These findings deserve further investigation given the existence of AURKA-inhibitors.
炎性乳腺癌（IBC）是一种罕见但侵袭性较强的乳腺癌亚型，主要通过原发性肿瘤样本进行特征描述。在这里，我们使用公共数据集，比较了转移性 IBC 患者和转移性非 IBC 患者的原发性和转移性样本中的基因组改变。我们观察到 IBC 中 AURKA 扩增的频率更高。我们进一步表明，AURKA 扩增与 AURKA mRNA 表达增加相关，我们证明 IBC 中的表达更高。最后，AURKA 的高蛋白表达与 IBC 患者的预后较差相关。鉴于存在 AURKA 抑制剂，这些发现值得进一步研究。
