Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Idaidori 2-1-1, Yahaba, Iwate, 028-3695, Japan.
Sci Rep. 2023 Jan 30;13(1):1648. doi: 10.1038/s41598-023-28528-w.
Sarcopenia is a common complication in patients with chronic liver disease (CLD); however, the progression of sarcopenia over the course of CLD is unclear. The present study therefore determined the natural course of the progression of sarcopenia in patients with CLD and the effect of liver cirrhosis (LC) on this progression. This observational study analyzed patients with chronic hepatitis (CH) (n = 536) and LC (n = 320) who underwent evaluations of the grip strength and skeletal muscle mass of the arms, trunk, and legs for sarcopenia between 2016 and 2021. A bioelectrical impedance analysis was used to evaluate skeletal muscle mass. The annual rate of change (%/year) in two tests were compared between patients with CH and LC. The annual rates of change in grip strength and skeletal muscle of arms, trunk, and legs of patients with CH and LC were - 0.84% vs. - 2.93%, - 0.54% vs. - 1.71%, - 0.43% vs. - 1.02%, and - 0.76% vs. - 1.70% for men and - 0.12% vs. - 1.71%, - 0.66% vs. - 1.71%, - 0.49% vs. - 1.31%, and - 0.76% vs. - 1.54% for women, respectively. The progression of sarcopenia was greater in LC patients than in CH patients and that the decrease in grip strength was most prominent in the progression of sarcopenia in patients with LC.
肌肉减少症是慢性肝病（CLD）患者的常见并发症；然而，CLD 患者肌肉减少症的进展情况尚不清楚。因此，本研究旨在确定 CLD 患者肌肉减少症的自然病程以及肝硬化（LC）对其进展的影响。本观察性研究分析了 2016 年至 2021 年间接受握力和手臂、躯干和腿部骨骼肌质量评估以筛查肌肉减少症的慢性肝炎（CH）（n=536）和 LC（n=320）患者。生物电阻抗分析用于评估骨骼肌质量。比较了 CH 和 LC 患者两项测试的年度变化率（%/年）。CH 和 LC 患者的握力和手臂、躯干和腿部骨骼肌的年度变化率分别为-0.84%比-2.93%、-0.54%比-1.71%、-0.43%比-1.02%和-0.76%比-1.70%，男性；-0.12%比-1.71%、-0.66%比-1.71%、-0.49%比-1.31%和-0.76%比-1.54%，女性。LC 患者的肌肉减少症进展大于 CH 患者，LC 患者肌肉减少症进展中握力下降最为明显。
