莫桑比克南部曼希卡5岁以下儿童异烟肼预防性治疗的起始与依从性

Initiation and adherence to isoniazid preventive therapy in children under 5 years of age in Manhiça, Southern Mozambique.

作者信息

Montoya I de Manuel-Rimbau Agnès, Nguenha Dinis, Mambuque Edson, Ehrlich Joanna, Munguambe Shilzia, Saavedra Belén, Matsena Teodimiro, Chiconela Hélio, Casellas Aina, López-Varela Elisa, Acacio Sozinho, Garcia-Basteiro Alberto L

机构信息

ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Centro de Investigação em Saude de Manhiça, Manhiça, Maputo, Mozambique.

出版信息

J Trop Pediatr. 2022 Dec 5;69(1). doi: 10.1093/tropej/fmad009.

DOI:10.1093/tropej/fmad009

PMID:36718019

Abstract

The WHO recommends preventive treatment for all pediatric contacts of a confirmed TB case, but coverage remains low in many high TB burden countries. We aimed to assess the coverage and adherence of the isoniazid preventive therapy (IPT) program among children under 5 years of age with household exposure to an adult pulmonary TB case in a rural district of Southern Mozambique. The estimated IPT coverage was 11.7%. A longer distance to the health center and lower age of the children hindered IPT initiation. Among patients who started IPT, 12/18 (69.9%) were adherent to the 6-month treatment.

摘要

世界卫生组织建议对所有确诊结核病病例的儿童接触者进行预防性治疗，但在许多结核病负担较高的国家，覆盖率仍然很低。我们旨在评估莫桑比克南部一个农村地区5岁以下因家庭接触成人肺结核病例而接受异烟肼预防性治疗（IPT）项目的覆盖率和依从性。IPT的估计覆盖率为11.7%。到卫生中心的距离较远以及儿童年龄较小阻碍了IPT的启动。在开始接受IPT治疗的患者中，18人中有12人（69.9%）坚持完成了6个月的治疗。