MedStar Genetic Medicine, MedStar Health, Columbia, MD, USA.
Department of Oncology, Georgetown University Medical Center, Washington, DC, USA.
Oncologist. 2023 Mar 17;28(3):189-192. doi: 10.1093/oncolo/oyac277.
Patients experience interindividual variation in response to analgesics, which may be partially explained by genetics. This commentary discusses a recently published trial on COMT genotype and opioid dose requirements and describes the potential role for COMT and other genes (eg, CYP2D6) on opioid therapy and the current evidence for germline pharmacogenetics and resources for opioid pharmacogenetics.
患者对镇痛药的反应存在个体间差异，这在一定程度上可以用遗传学来解释。本文讨论了最近发表的一项关于 COMT 基因型和阿片类药物剂量需求的试验，并描述了 COMT 和其他基因（如 CYP2D6）在阿片类药物治疗中的潜在作用，以及目前关于种系药物遗传学和阿片类药物遗传药理学资源的证据。
