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糖尿病患者侵袭性真菌性中耳炎:基于病例的回顾。

Invasive Fungal Otitis Media in Diabetic Patients: A Case-Based Review.

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Peking University, Peking University People's Hospital, Beijing, China.

Department of Otorhinolaryngology, Head and Neck Surgery, Capital Medical University, Beijing Friendship Hospital, Beijing, China.

出版信息

J Int Adv Otol. 2023 Jan;19(1):55-60. doi: 10.5152/iao.2023.22743.

DOI:10.5152/iao.2023.22743
PMID:36718038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9984921/
Abstract

BACKGROUND

Invasive fungal otitis media is clinically rare. The clinical features are often atypical in the early stages of the disease, and delayed treatment results in poor outcomes.

METHODS

In this study, we report 2 patients with invasive fungal otitis media with diabetes. The early diagnosis was confirmed by comprehensive methods such as laboratory tests and imaging examinations, and the condition was significantly improved by antifungal drugs and surgical treatment.

RESULTS

By reviewing the literature, we found that invasive fungal infections confined to the middle ear and mastoid were rarely reported, and the diagnosis and treatment were still controversial.

CONCLUSION

In this article, we summarized and evaluated the different diagnoses and treatment methods so as to better diagnose and improve the cure rate in the early stage of invasive fungal infection of the middle ear.

摘要

背景

侵袭性真菌性中耳炎临床上罕见。疾病早期的临床特征往往不典型,治疗延误导致预后不良。

方法

本研究报道了 2 例糖尿病合并侵袭性真菌性中耳炎患者。通过实验室检查和影像学检查等综合方法早期确诊,并通过抗真菌药物和手术治疗显著改善病情。

结果

通过文献复习发现,局限于中耳和乳突的侵袭性真菌感染少见,诊断和治疗仍存在争议。

结论

本文总结评估了不同的诊断和治疗方法,以期在中耳侵袭性真菌感染的早期更好地诊断和提高治愈率。

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Invasive Fungal Otitis Media in Diabetic Patients: A Case-Based Review.糖尿病患者侵袭性真菌性中耳炎:基于病例的回顾。
J Int Adv Otol. 2023 Jan;19(1):55-60. doi: 10.5152/iao.2023.22743.
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Scedosporium apiospermum infections in the middle ear and mastoid: case series and review of the literature.耳中和乳突中的枝顶孢属感染:病例系列和文献回顾。
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Surgery of the mastoid in ears with middle ear effusion.
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[Extended atticoantromastoidectomy in the treatment of various forms of chronic otitis media].
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Mastoid and middle ear cavity obliteration for control of otitis media.
Ann Otol Rhinol Laryngol. 1976 May-Jun;85(3 pt 1):305-9. doi: 10.1177/000348947608500301.
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Surgical advances in treating otitis media.治疗中耳炎的外科进展。
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Mastoidectomy for chronic serous otitis media.
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Hearing results of surgery for chronic otitis media without cholesteatoma.无胆脂瘤型慢性中耳炎的手术听力结果。
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Clin Case Rep. 2025 Jan 20;13(1):e70101. doi: 10.1002/ccr3.70101. eCollection 2025 Jan.
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Invasive fungal otitis media with peripheral facial paralysis.侵袭性真菌性中耳炎伴周围性面瘫
Med Mycol Case Rep. 2024 Sep 27;46:100672. doi: 10.1016/j.mmcr.2024.100672. eCollection 2024 Dec.

本文引用的文献

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Invasive Is the Sole Etiological Agent for CSOM : A Clinical Case from Nepal.侵袭性是慢性化脓性中耳炎的唯一病因:来自尼泊尔的一个临床病例
Case Rep Infect Dis. 2021 Sep 27;2021:5556679. doi: 10.1155/2021/5556679. eCollection 2021.
2
Aspergillus flavus malignant external otitis in a diabetic patient: case report and literature review.黄曲霉菌致糖尿病患者恶性外耳道炎 1 例并文献复习
Infection. 2020 Apr;48(2):193-203. doi: 10.1007/s15010-020-01394-8. Epub 2020 Feb 8.
3
Comparative evaluation of galactomannan test with bronchoalveolar lavage and serum for the diagnosis of invasive aspergillosis in patients with hematological malignancies.
半乳甘露聚糖检测与支气管肺泡灌洗及血清在血液系统恶性肿瘤患者侵袭性曲霉病诊断中的比较评估
J Lab Physicians. 2017 Oct-Dec;9(4):234-238. doi: 10.4103/JLP.JLP_127_16.
4
A case of hypertrophic cranial pachymeningitis associated with invasive Aspergillus mastoiditis.一例与侵袭性曲霉性乳突炎相关的肥厚性颅骨硬脑膜炎病例。
Auris Nasus Larynx. 2015 Dec;42(6):488-91. doi: 10.1016/j.anl.2015.04.009. Epub 2015 May 21.
5
Aspergillus mastoiditis in an immunocompetent patient: a case report and review of the literature.免疫功能正常患者的曲霉性乳突炎:一例病例报告及文献综述
Scand J Infect Dis. 2014 Apr;46(4):325-30. doi: 10.3109/00365548.2013.867073. Epub 2014 Feb 3.
6
β-D-glucan assay for the diagnosis of invasive fungal infections: a meta-analysis.β-D-葡聚糖检测用于侵袭性真菌感染的诊断:一项荟萃分析。
Clin Infect Dis. 2011 Mar 15;52(6):750-70. doi: 10.1093/cid/ciq206.
7
Diagnostic contribution of positron emission tomography with [18F]fluorodeoxyglucose for invasive fungal infections.正电子发射断层扫描(PET)用 [18F]氟脱氧葡萄糖对侵袭性真菌感染的诊断作用。
Clin Microbiol Infect. 2011 Mar;17(3):409-17. doi: 10.1111/j.1469-0691.2010.03301.x.
8
Antifungal therapy of Aspergillus invasive otitis externa: efficacy of voriconazole and review.侵袭性外耳道曲霉病的抗真菌治疗:伏立康唑的疗效及综述
Antimicrob Agents Chemother. 2009 Mar;53(3):1048-53. doi: 10.1128/AAC.01220-08. Epub 2008 Dec 22.
9
Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.欧洲癌症研究与治疗组织/侵袭性真菌感染合作组和美国国立过敏与传染病研究所真菌病研究组(EORTC/MSG)共识组对侵袭性真菌病的修订定义。
Clin Infect Dis. 2008 Jun 15;46(12):1813-21. doi: 10.1086/588660.
10
Invasive Aspergillus of the temporal bone.颞骨侵袭性曲霉病
Am J Otolaryngol. 2007 Mar-Apr;28(2):134-6. doi: 10.1016/j.amjoto.2006.07.004.