Misael Chinchilla C, Olga Marta Guerrero B, Roberto Marín R
Depto. Parasitología, Facultad de Microbiología, Universidad de Costa Rica.
Rev Biol Trop. 1986 Jun;34(1):1-6.
White mice previously infected with 10(2), 10(3) or 10(4) Eimeria falciformis oocysts on days 0, 5, 10 or 30 were inoculated per os with 10(1), 10(2), 10(3) or 10(4) Toxoplasma oocysts. While the results obtained for mice with higher Toxoplasma inocula were consistent, animals with 10(1) and 10(2) oocysts previous inoculation with Eimeria showed important differences related with those infected only with Toxoplasma. For example, survival time was higher in animals infected with both parasites, especially if inoculated with Eimeria 30 days before Toxoplasma infection. Furthermore the number of T. gondii cysts found in the animals previously infected with Eimeria was lower compared with mice inoculated with Toxoplasma only. Body weight of mice infected with Toxoplasma previous infection with Eimeria was almost normal in relation to those infected only with Toxoplasma, indicating a probable pathological effect due to the parasite, more evident in "non immunized" mice.
在第0、5、10或30天预先感染10²、10³或10⁴个镰形艾美耳球虫卵囊的小白鼠，经口接种10¹、10²、10³或10⁴个弓形虫卵囊。虽然接种较高剂量弓形虫的小鼠所获结果是一致的，但先前接种10¹和10²个卵囊的艾美耳球虫的动物与仅感染弓形虫的动物相比存在重要差异。例如，感染两种寄生虫的动物存活时间更长，尤其是在弓形虫感染前30天接种艾美耳球虫的情况下。此外，与仅接种弓形虫的小鼠相比，先前感染艾美耳球虫的动物体内发现的弓形虫囊肿数量更少。先前感染艾美耳球虫后又感染弓形虫的小鼠体重与仅感染弓形虫的小鼠相比几乎正常，这表明该寄生虫可能产生病理效应，在“未免疫”小鼠中更为明显。
