Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri, Columbia, Missouri, Mo, USA.
Department of Pediatrics, Right Way (Germany) Heidekreis-Klinikum GmbH Krankenhaus Walsrode, Walsrode, Germany.
Recent Adv Inflamm Allergy Drug Discov. 2023;17(1):79-84. doi: 10.2174/2772270817666230130093341.
Lymphocytic esophagitis (LE) is a poorly understood clinical finding that has been increasingly identified in the last decade. Previous studies proposed increased frequency of LE in elderly females, as well as associations with smoking and pediatric Crohn's disease.
We aimed to determine the patient characteristics and clinical features of our adult LE patients. As inflammation in the esophagus has been linked to cancer, this review also describes this association. However, there are no reported cases of malignant transformation in those with underlying lymphocytic esophagitis.
We retrospectively reviewed records for patients at the University of Missouri Hospital- Columbia (located in the USA) who had a histopathological diagnosis of LE. Cases of LE were identified using the pathology reporting system at the University of Missouri Hospital for esophageal biopsy specimens for the above-mentioned period.
The data of a total of 20 adult cases with esophageal biopsy specimens consistent with LE were included.
LE seems to be a benign but disturbing clinical problem and should be remembered in elderly females complaining of dysphagia or refractory reflux symptoms. It has similar endoscopic findings of eosinophilic esophagitis with rings and esophagitis. Smoking and hiatal hernia are common risk factors. The majority of LE patients can respond to proton pump inhibitor (PPI) therapy. Endoscopic dilations and steroid therapy should be considered for PPI nonresponder LE patients.
淋巴细胞性食管炎 (LE) 是一种尚未被充分了解的临床发现，在过去十年中越来越多地被识别出来。先前的研究表明，LE 在老年女性中的发病率较高，与吸烟和儿童克罗恩病有关。
我们旨在确定我们的成人 LE 患者的患者特征和临床特征。由于食管炎症与癌症有关，因此本综述还描述了这种关联。然而，在那些患有潜在淋巴细胞性食管炎的人中，没有报告恶性转化的病例。
我们回顾性地审查了位于美国密苏里大学医院-哥伦比亚（位于美国）的患者记录，这些患者的食管活检标本有组织病理学诊断为 LE。在上述期间，使用密苏里大学医院的病理学报告系统确定 LE 病例。
共纳入了 20 例食管活检标本符合 LE 的成年病例的数据。
LE 似乎是一种良性但令人不安的临床问题，对于有吞咽困难或难治性反流症状的老年女性应予以注意。它具有与嗜酸性食管炎相似的内镜表现，如环和食管炎。吸烟和食管裂孔疝是常见的危险因素。大多数 LE 患者对质子泵抑制剂 (PPI) 治疗有反应。对于 PPI 无反应的 LE 患者，应考虑内镜扩张和类固醇治疗。
