Machiya Seigo, Nakazawa Shigeaki, Fukae Shota, Tanaka Ryo, Taniguchi Ayumu, Yamanaka Kazuaki, Takahara Shiro, Namba-Hamano Tomoko, Imamura Ryoichi, Nonomura Norio
Department of Urology Osaka University Graduate School of Medicine Suita Osaka Japan.
Kansai Medical Hospital Renal Transplantation Clinic Toyonaka Osaka Japan.
IJU Case Rep. 2022 Dec 16;6(2):120-3. doi: 10.1002/iju5.12566.
The coronavirus disease 2019 pandemic emerged in December 2019. Renal transplant recipients receiving chronic immunosuppression are considered to be at a high risk of infection. Aside from upper respiratory tract symptoms, coronavirus disease 2019 has also been reported to cause acute kidney injury in 20-50% of infected cases.
A 62-year-old male renal transplant recipient presented with high fever, diarrhea, and cough, concurrent with rapid deterioration of graft function. The patient tested positive for coronavirus disease 2019. The pathological findings of the graft biopsy revealed diffuse flattening of tubular epithelial cells and extensive loss of the brush border in proximal tubular cells. Mycophenolate mofetil was discontinued and sotrovimab, remdesivir, intravenous immunoglobulin, and intravenous methylprednisolone were administered, resulting in gradual improvements in clinical symptoms and renal function.
We describe a case of a coronavirus disease 2019-infected kidney transplant recipient who developed severe acute kidney injury caused by severe acute tubular necrosis.
2019年12月出现了2019冠状病毒病大流行。接受慢性免疫抑制的肾移植受者被认为感染风险很高。除上呼吸道症状外，据报道，2019冠状病毒病在20%至50%的感染病例中还会导致急性肾损伤。
一名62岁男性肾移植受者出现高热、腹泻和咳嗽，同时移植肾功能迅速恶化。该患者2019冠状病毒病检测呈阳性。移植肾活检的病理结果显示肾小管上皮细胞弥漫性扁平，近端肾小管细胞刷状缘广泛丧失。停用霉酚酸酯，并给予索托维单抗、瑞德西韦、静脉注射免疫球蛋白和静脉注射甲泼尼龙，临床症状和肾功能逐渐改善。
我们描述了一例2019冠状病毒病感染的肾移植受者病例，该患者因严重急性肾小管坏死而发生严重急性肾损伤。
