Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Oxid Med Cell Longev. 2023 Jan 19;2023:8206298. doi: 10.1155/2023/8206298. eCollection 2023.
To investigate the relationship between peripheral blood total bilirubin (TBIL) levels and the risk of primary open-angle glaucoma (POAG).
This study was a cross-sectional, case-control study design. Between April 2021 and January 2022, 198 POAG patients and 205 healthy subjects were recruited from the EENT Hospital of Fudan University. Their clinical information (intraocular pressure, central corneal thickness, vertical cup-disk ratios (VCDR), and axial length) and demographic data were collected. Serum levels of TBIL were measured in enzymes using a Roche C702 biochemical analyzer. The POAG subgroups were classified by gender and VCDR: mild (VCDR ≤ 0.64), moderate (VCDR ≤ 0.85), and severe (VCDR > 0.85). Univariate and multivariate logistic regression analyses were performed.
The level of TBIL (11.58 ± 5.16 mol/L) in the POAG group was higher than that in the control group (10.18 ± 3.38 mol/L; < 0.05). In the male subgroup, TBIL was also significantly higher than in the normal control group; TBIL levels were lower in the mild subgroup (10.82 ± 4.48 mol/L), followed by the moderate subgroup (12.00 ± 5.55 mol/L) and the severe subgroup (14.47 ± 5.45 mol/L). The results of the multivariate logistic regression analysis showed that high TBIL levels were a risk factor for male POAG, at 1.126 (95% CI 1.009-1.256). Pearson's analysis revealed that TBIL was positively correlated with intraocular pressure ( = 0.134, = 0.012), VCDR ( = 0.142, = 0.046), anterior chamber depth ( = 0.190, = 0.014), and axial length ( = 0.179, = 0.019) in the patients. However, no statistical difference ( < 0.05) was observed in the female patients with POAG.
The results showed that high levels of TBIL may be related to the pathogenesis of POAG and that the severity of the disease is positively correlated, especially in male patients.
探讨外周血总胆红素（TBIL）水平与原发性开角型青光眼（POAG）风险的关系。
本研究为横断面病例对照研究设计。2021 年 4 月至 2022 年 1 月，从复旦大学 EENT 医院招募了 198 例 POAG 患者和 205 名健康对照者。收集他们的临床信息（眼压、中央角膜厚度、垂直杯盘比（VCDR）和眼轴长度）和人口统计学数据。使用罗氏 C702 生化分析仪酶法检测血清 TBIL 水平。根据性别和 VCDR 将 POAG 亚组分类：轻度（VCDR≤0.64）、中度（VCDR≤0.85）和重度（VCDR＞0.85）。进行单因素和多因素 logistic 回归分析。
POAG 组 TBIL 水平（11.58±5.16μmol/L）高于对照组（10.18±3.38μmol/L；<0.05）。在男性亚组中，TBIL 也明显高于正常对照组；TBIL 水平在轻度亚组中较低（10.82±4.48μmol/L），其次是中度亚组（12.00±5.55μmol/L）和重度亚组（14.47±5.45μmol/L）。多因素 logistic 回归分析结果表明，TBIL 水平升高是男性 POAG 的危险因素，比值比为 1.126（95%置信区间 1.009-1.256）。Pearson 分析显示，TBIL 与患者的眼压（ = 0.134， = 0.012）、VCDR（ = 0.142， = 0.046）、前房深度（ = 0.190， = 0.014）和眼轴长度（ = 0.179， = 0.019）呈正相关。然而，在 POAG 女性患者中，这些相关性无统计学差异（<0.05）。
结果表明，TBIL 水平升高可能与 POAG 的发病机制有关，且与疾病的严重程度呈正相关，尤其是在男性患者中。
