Koklesova Lenka, Samec Marek, Liskova Alena, Zhai Kevin, Büsselberg Dietrich, Giordano Frank A, Kubatka Peter, Golunitschaja Olga
Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, 24144 Qatar.
EPMA J. 2021 Mar 4;12(1):27-40. doi: 10.1007/s13167-021-00237-2. eCollection 2021 Mar.
Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a "vicious circle" characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled ROS release, diminished energy production and extensive oxidative stress to life-important biomolecules such as mtDNA and chrDNA), individual outcomes differ significantly representing a spectrum of associated pathologies including but not restricted to neurodegeneration, cardiovascular diseases and cancers. Contextually, the role of predictive, preventive and personalised (PPPM/3P) medicine is to introduce predictive analytical approaches which allow for distinguishing between individual outcomes under circumstance of mitochondrial impairments followed by cost-effective targeted prevention and personalisation of medical services. Current article considers innovative concepts and analytical instruments to advance management of mitochondriopathies and associated pathologies.
线粒体损伤在多因素疾病的病因病理学中起着关键作用，这些疾病表现出一种“恶性循环”的特征，这种特征常见于线粒体和多器官损伤的病理机制中，且二者损伤常以相互作用的方式频繁发生。尽管损伤的起源是共同的（活性氧不受控制地释放、能量产生减少以及对诸如线粒体DNA和染色体DNA等重要生命生物分子产生广泛的氧化应激），但个体结果差异显著，代表了一系列相关病理，包括但不限于神经退行性疾病、心血管疾病和癌症。在此背景下，预测性、预防性和个性化（PPPM/3P）医学的作用是引入预测性分析方法，以便在出现线粒体损伤的情况下区分个体结果，随后进行具有成本效益的针对性预防和医疗服务个性化。本文探讨了创新概念和分析工具，以推进线粒体疾病及相关病理的管理。
