Sun Shulin, Wang Peng, Yue Kaifeng, Yi Qipeng, Xie Xinjun, Xie Xianmin
Hunan University of Chinese Medicine, Changsha 410208, Hunan, China.
Department of External Hand Trauma, The First Affiliated Hospital of Hunan University of Chinese Medicine, No. 95, Shaoshan Middle Road, Yuhua District, Changsha City, Hunan Province, China.
Evid Based Complement Alternat Med. 2023 Jan 21;2023:6122331. doi: 10.1155/2023/6122331. eCollection 2023.
This study aimed to explore the effect and mechanism of Dragon's Blood on wound healing in patients with a pressure hand injury. A total of 120 patients with pressure hand injury treated in our hospital were randomly divided into two groups. Sixty patients in the control group were dressed with sterile gauze, and 60 patients in the observation group were smeared with blood exhaustion. The clinical effects and serological indexes of the two groups were compared, and the mechanism of wound healing was analyzed. The results showed that the treatment effective rate of the control group was 80% and that of the observation group was 93.33%. The treatment effective rate of the observation group was dramatically higher ( < 0.05). The number of patients with good granulation tissue in the observation group was 53, which was dramatically greater than that in the control group. The number of patients with a small amount of wound exudation was 51, which was dramatically greater than that in the control group ( < 0.05). After treatment, the levels of matrix metalloproteinase (MMP-3), vascular endothelial growth factor (VEGF), and transforming growth factor B1 (TGF-B1) in the observation group increased more dramatically ( < 0.05). The level of tissue inhibitor of metalloproteinase-1 (TIMP-1) decreased to 617.23 ng/L in the observation group, and the degree of reduction was more obvious ( < 0.05). Notably, Dragon's Blood promoted wound healing at the injury site by increasing the levels of MMP-3, VEGF, and TGF-B1and decreasing TIMP-1. The area of wound reduction in the observation group was 0.27 cm, and the reduction was more obvious ( < 0.05). The healing time of pressure hand injury in the observation group was 15.27 days, which was dramatically shorter ( < 0.05). In summary, Dragon's Blood had a good effect on the healing of the injured site in patients with pressure hand injury, which is worthy of promotion.
本研究旨在探讨血竭对压砸伤手部患者伤口愈合的影响及机制。选取我院收治的120例压砸伤手部患者，随机分为两组。对照组60例患者采用无菌纱布包扎，观察组60例患者采用血竭涂抹。比较两组的临床疗效和血清学指标，并分析伤口愈合机制。结果显示，对照组治疗有效率为80%，观察组为93.33%。观察组治疗有效率显著更高（P<0.05）。观察组肉芽组织生长良好的患者有53例，显著多于对照组。伤口渗液量少的患者有51例，显著多于对照组（P<0.05）。治疗后，观察组基质金属蛋白酶（MMP-3）、血管内皮生长因子（VEGF）和转化生长因子β1（TGF-β1）水平升高更显著（P<0.05）。观察组金属蛋白酶组织抑制剂-1（TIMP-1）水平降至617.23 ng/L，下降程度更明显（P<0.05）。值得注意的是，血竭通过提高MMP-3、VEGF和TGF-β1水平以及降低TIMP-1促进损伤部位伤口愈合。观察组伤口缩小面积为0.27 cm，缩小更明显（P<0.05）。观察组压砸伤手部愈合时间为15.27天，显著更短（P<0.05）。综上所述，血竭对压砸伤手部患者损伤部位的愈合有良好效果，值得推广。
