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穿透性角膜移植术后角膜积血眼行深板层角膜移植术中的基质剥离术

Stromal peeling for deep anterior lamellar keratoplasty in a post-penetrating keratoplasty eye with hematocornea.

作者信息

Scorcia Vincenzo, Giannaccare Giuseppe, Pellegrini Marco, Camposampiero Davide, Ponzin Diego, Yu Angeli Christy, Busin Massimo

机构信息

Department of Ophthalmology, University Magna Graecia of Catanzaro, Catanzaro, Italy.

University of Ferrara, Department of Translational Medicine, Ferrara, Italy.

出版信息

Am J Ophthalmol Case Rep. 2023 Jan 22;29:101808. doi: 10.1016/j.ajoc.2023.101808. eCollection 2023 Mar.

Abstract

PURPOSE

To present a case of hematocornea occurring in a post-penetrating keratoplasty (PK) eye and to report the outcomes of deep anterior lamellar keratoplasty (DALK) performed by simple stromal peeling.

OBSERVATIONS

A 45-year-old female presented with hematocornea in the left eye that previously underwent PK 26 months prior for keratoconus. Clinical examination revealed a dense reddish-brown opacity within the PK graft which was associated with deep corneal neovascularization. Over 6 months, intracorneal hemorrhage developed a rust-colored appearance with minimal clearing. DALK was performed using the stromal peeling technique for post-PK eyes. Briefly, a dense partially organized hemorrhage was identified at the natural plane of separation, as confirmed by ex vivo histologic examination; after peeling of the deep corneal stroma and evacuation of the intracorneal hemorrhage, the residual bed appeared akin to pre-Descemet's layer-Descemet membrane-endothelium complex. One year after DALK, the graft remained clear with ECD of 1034 cells/mm.

CONCLUSIONS AND IMPORTANCE

Intracorneal hemorrhage is a rare but potentially sight-threatening complication following PK. Using the stromal peeling technique, DALK can be attempted to preserve functional endothelium in post-PK eyes. In the presence of a dense intracorneal hemorrhage, the spread of erythrocytic debris within the stroma can guide deep lamellar cleavage.

摘要

目的

报告1例穿透性角膜移植术(PK)后发生角膜积血的病例,并报道通过简单基质剥离进行的深板层角膜移植术(DALK)的结果。

观察结果

一名45岁女性,左眼出现角膜积血,该眼26个月前因圆锥角膜接受了PK手术。临床检查发现PK植片内有致密的红棕色混浊,伴有角膜深层新生血管形成。在6个月的时间里,角膜内出血呈现铁锈色外观,几乎没有消退。对PK术后眼采用基质剥离技术进行DALK手术。简要介绍如下,经体外组织学检查证实,在自然分离平面发现致密的部分机化出血;剥除角膜深层基质并清除角膜内出血后,残留床类似于后弹力层-后弹力膜-内皮细胞复合体。DALK术后1年,植片保持透明,内皮细胞密度为1034个/mm²。

结论与意义

角膜内出血是PK术后一种罕见但可能威胁视力的并发症。采用基质剥离技术,可以尝试在PK术后眼中保留功能性内皮细胞。在存在致密角膜内出血的情况下,红细胞碎片在基质内的扩散可指导深层板层分离。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431a/9883201/5319fe70333f/gr1.jpg

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