• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

穿透性角膜移植术后角膜积血眼行深板层角膜移植术中的基质剥离术

Stromal peeling for deep anterior lamellar keratoplasty in a post-penetrating keratoplasty eye with hematocornea.

作者信息

Scorcia Vincenzo, Giannaccare Giuseppe, Pellegrini Marco, Camposampiero Davide, Ponzin Diego, Yu Angeli Christy, Busin Massimo

机构信息

Department of Ophthalmology, University Magna Graecia of Catanzaro, Catanzaro, Italy.

University of Ferrara, Department of Translational Medicine, Ferrara, Italy.

出版信息

Am J Ophthalmol Case Rep. 2023 Jan 22;29:101808. doi: 10.1016/j.ajoc.2023.101808. eCollection 2023 Mar.

DOI:10.1016/j.ajoc.2023.101808
PMID:36718436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9883201/
Abstract

PURPOSE

To present a case of hematocornea occurring in a post-penetrating keratoplasty (PK) eye and to report the outcomes of deep anterior lamellar keratoplasty (DALK) performed by simple stromal peeling.

OBSERVATIONS

A 45-year-old female presented with hematocornea in the left eye that previously underwent PK 26 months prior for keratoconus. Clinical examination revealed a dense reddish-brown opacity within the PK graft which was associated with deep corneal neovascularization. Over 6 months, intracorneal hemorrhage developed a rust-colored appearance with minimal clearing. DALK was performed using the stromal peeling technique for post-PK eyes. Briefly, a dense partially organized hemorrhage was identified at the natural plane of separation, as confirmed by ex vivo histologic examination; after peeling of the deep corneal stroma and evacuation of the intracorneal hemorrhage, the residual bed appeared akin to pre-Descemet's layer-Descemet membrane-endothelium complex. One year after DALK, the graft remained clear with ECD of 1034 cells/mm.

CONCLUSIONS AND IMPORTANCE

Intracorneal hemorrhage is a rare but potentially sight-threatening complication following PK. Using the stromal peeling technique, DALK can be attempted to preserve functional endothelium in post-PK eyes. In the presence of a dense intracorneal hemorrhage, the spread of erythrocytic debris within the stroma can guide deep lamellar cleavage.

摘要

目的

报告1例穿透性角膜移植术(PK)后发生角膜积血的病例,并报道通过简单基质剥离进行的深板层角膜移植术(DALK)的结果。

观察结果

一名45岁女性,左眼出现角膜积血,该眼26个月前因圆锥角膜接受了PK手术。临床检查发现PK植片内有致密的红棕色混浊,伴有角膜深层新生血管形成。在6个月的时间里,角膜内出血呈现铁锈色外观,几乎没有消退。对PK术后眼采用基质剥离技术进行DALK手术。简要介绍如下,经体外组织学检查证实,在自然分离平面发现致密的部分机化出血;剥除角膜深层基质并清除角膜内出血后,残留床类似于后弹力层-后弹力膜-内皮细胞复合体。DALK术后1年,植片保持透明,内皮细胞密度为1034个/mm²。

结论与意义

角膜内出血是PK术后一种罕见但可能威胁视力的并发症。采用基质剥离技术,可以尝试在PK术后眼中保留功能性内皮细胞。在存在致密角膜内出血的情况下,红细胞碎片在基质内的扩散可指导深层板层分离。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431a/9883201/7f4700520334/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431a/9883201/5319fe70333f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431a/9883201/fb9b05dc2dd2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431a/9883201/7f4700520334/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431a/9883201/5319fe70333f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431a/9883201/fb9b05dc2dd2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431a/9883201/7f4700520334/gr3.jpg

相似文献

1
Stromal peeling for deep anterior lamellar keratoplasty in a post-penetrating keratoplasty eye with hematocornea.穿透性角膜移植术后角膜积血眼行深板层角膜移植术中的基质剥离术
Am J Ophthalmol Case Rep. 2023 Jan 22;29:101808. doi: 10.1016/j.ajoc.2023.101808. eCollection 2023 Mar.
2
Stromal peeling for deep anterior lamellar keratoplasty in post-penetrating keratoplasty eyes.穿透性角膜移植术后眼行深板层角膜移植的基质剥离术
Br J Ophthalmol. 2022 Mar;106(3):336-340. doi: 10.1136/bjophthalmol-2020-316653. Epub 2020 Nov 26.
3
Comparison of femtosecond laser-assisted deep anterior lamellar keratoplasty and penetrating keratoplasty for keratoconus.飞秒激光辅助深板层角膜移植术与穿透性角膜移植术治疗圆锥角膜的比较。
BMC Ophthalmol. 2015 Oct 27;15:144. doi: 10.1186/s12886-015-0140-x.
4
Phacoemulsification Under the Complex Dua Layer-Descemet-Endothelium for Combined Cataract Surgery and Penetrating Keratoplasty After Failed Deep Anterior Lamellar Keratoplasty.复杂双层-Descemet 内皮下超声乳化在深板层角膜移植术后失败的穿透性角膜移植联合白内障手术中的应用。
Cornea. 2023 Oct 1;42(10):1297-1300. doi: 10.1097/ICO.0000000000003338. Epub 2023 Jul 4.
5
Indications of Keratoplasty and Outcomes of Deep Anterior Lamellar Keratoplasty Compared to Penetrating Keratoplasty.角膜移植术的适应症以及与穿透性角膜移植术相比的深板层角膜移植术的结果
Cureus. 2021 Mar 11;13(3):e13825. doi: 10.7759/cureus.13825.
6
Infectious interface keratitis (IIK) following lamellar keratoplasty: A literature review.感染性界面性角膜炎(IIK)在板层角膜移植术后:文献回顾。
Ocul Surf. 2019 Oct;17(4):635-643. doi: 10.1016/j.jtos.2019.08.001. Epub 2019 Aug 12.
7
Influence of graft-host interface on the quality of vision after deep anterior lamellar keratoplasty in patients with keratoconus.圆锥角膜患者行深板层角膜移植术后植片-宿主界面影响视觉质量。
Cornea. 2011 May;30(5):497-502. doi: 10.1097/ico.0b013e3181d25e4d.
8
[Intracorneal selective stromal transplantation].[角膜基质选择性移植术]
Vestn Oftalmol. 2024;140(1):86-92. doi: 10.17116/oftalma202414001186.
9
[Deep anterior lamellar keratoplasty in keratoconus].
Srp Arh Celok Lek. 2011 Jan-Feb;139(1-2):88-91. doi: 10.2298/sarh1102088n.
10
Complications in deep anterior lamellar keratoplasty - A retrospective interventional analysis in a large series.深部前弹力层角膜移植术的并发症:一项大型系列回顾性干预分析。
Indian J Ophthalmol. 2022 Oct;70(10):3501-3507. doi: 10.4103/ijo.IJO_655_22.

引用本文的文献

1
Recurrence of hematocornea with intraocular neoplasm.伴有眼内肿瘤的角膜血化复发。
Am J Ophthalmol Case Rep. 2025 Jun 27;39:102372. doi: 10.1016/j.ajoc.2025.102372. eCollection 2025 Sep.
2
Large-diameter deep anterior lamellar keratoplasty: A narrative review.大直径深前板层角膜移植术:一项叙述性综述。
Taiwan J Ophthalmol. 2024 Feb 23;14(1):27-33. doi: 10.4103/tjo.TJO-D-23-00161. eCollection 2024 Jan-Mar.
3
Microsporidial Stromal Keratitis in Post-Keratoplasty Eyes.角膜移植术后眼的微孢子虫性基质性角膜炎

本文引用的文献

1
Ultrastructural Alterations of Grafted Corneal Buttons: The Anatomic Basis for Stromal Peeling Along a Natural Plane of Separation.移植角膜纽扣的超微结构改变:沿天然分离面进行基质剥离的解剖学基础。
Am J Ophthalmol. 2021 Nov;231:144-153. doi: 10.1016/j.ajo.2021.06.005. Epub 2021 Jun 10.
2
Corneal neovascularisation following deep anterior lamellar keratoplasty for corneal ectasia: incidence, timing and risk factors.深板层角膜移植术后角膜扩张的角膜新生血管:发生率、时间和危险因素。
Br J Ophthalmol. 2022 Oct;106(10):1363-1367. doi: 10.1136/bjophthalmol-2021-319339. Epub 2021 May 13.
3
Stromal peeling for deep anterior lamellar keratoplasty in post-penetrating keratoplasty eyes.
J Clin Med. 2023 May 27;12(11):3706. doi: 10.3390/jcm12113706.
穿透性角膜移植术后眼行深板层角膜移植的基质剥离术
Br J Ophthalmol. 2022 Mar;106(3):336-340. doi: 10.1136/bjophthalmol-2020-316653. Epub 2020 Nov 26.
4
Optimizing outcomes for keratoplasty in ectatic corneal disease.优化扩张性角膜疾病角膜移植术的结果。
Curr Opin Ophthalmol. 2020 Jul;31(4):268-275. doi: 10.1097/ICU.0000000000000666.
5
Spontaneous Descemet Membrane Detachment 20 Years After Penetrating Keratoplasty for Keratoconus.圆锥角膜穿透性角膜移植术后20年发生的自发性后弹力层脱离
Cornea. 2016 Jul;35(7):1023-5. doi: 10.1097/ICO.0000000000000873.
6
Small-bubble deep anterior lamellar keratoplasty technique.小气泡深板层角膜移植术技术
JAMA Ophthalmol. 2014 Nov;132(11):1369-71. doi: 10.1001/jamaophthalmol.2014.2756.
7
Human corneal anatomy redefined: a novel pre-Descemet's layer (Dua's layer).人类角膜解剖结构的重新定义:一种新的前 Descemet 膜(Dua 层)。
Ophthalmology. 2013 Sep;120(9):1778-85. doi: 10.1016/j.ophtha.2013.01.018. Epub 2013 May 25.
8
Retrocorneal membrane after penetrating keratoplasty.穿透性角膜移植术后的角膜后膜
Ophthalmic Surg Lasers. 2001 Mar-Apr;32(2):159-61.
9
Corneal blood staining after hyphaema.前房积血后的角膜血染
Br J Ophthalmol. 1972 Aug;56(8):589-93. doi: 10.1136/bjo.56.8.589.
10
Blood staining of the cornea. Light microscopic and ultrastructural features.
Ophthalmology. 1985 Dec;92(12):1668-74. doi: 10.1016/s0161-6420(85)34089-7.