Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Department of Sociology and Psychology, School of Public Administration, 12530Sichuan University, Chengdu, China.
Sci Prog. 2023 Jan-Mar;106(1):368504221145541. doi: 10.1177/00368504221145541.
This study assesses the extent to which the association between erythrocyte sedimentation rate, a marker of inflammation, and cognitive function is explained by shared familial factors using within-sibling analyses. Men who were born in Sweden between 1950 and 1965 and recorded in the Swedish Military Conscription Register between 1969 and 1983 were included ( = 632,396). Erythrocyte sedimentation rate and cognitive function were measured at the conscription assessment (median age = 18.3 years, with a range from 15.5 to 28.5 years). Conventional linear regression and multilevel linear regression with a hybrid modeling approach were used, with the latter to obtain within-effect estimation in which unmeasured familial confounding shared by siblings was controlled for. We found that the association between erythrocyte sedimentation rate and cognitive function at conscription assessment was partly accounted for by, but remained independent of, shared familial factors.
本研究采用同胞内分析，评估红细胞沉降率（炎症标志物）与认知功能之间的关联在多大程度上可以用共同的家族因素来解释。纳入了在瑞典出生于 1950 年至 1965 年且在 1969 年至 1983 年间被瑞典兵役登记处记录的男性（n=632396）。在兵役评估时测量了红细胞沉降率和认知功能（中位数年龄为 18.3 岁，范围为 15.5 岁至 28.5 岁）。采用常规线性回归和混合建模方法的多层次线性回归，后者用于获得内部效应估计，以控制兄弟姐妹共同的未测量家族混杂因素。我们发现，兵役评估时红细胞沉降率与认知功能之间的关联部分可以用共同的家族因素来解释，但仍然独立于这些因素。
