Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan.
PRESTO, Japan Science and Technology Agency, Chiyoda-ku, Japan.
Dev Growth Differ. 2023 Apr;65(3):161-166. doi: 10.1111/dgd.12842. Epub 2023 Feb 14.
Eukaryotic cells fold their membranes into highly organized structures called membrane-bound organelles. Organelles display characteristic structures and perform specialized functions related to their structures. Focusing on the Golgi apparatus, we provide an overview of recent theoretical studies to explain the mechanism of the architecture of the Golgi apparatus. These studies are classified into two categories: those that use equilibrium models to describe the robust Golgi morphology and those that use non-equilibrium models to explain the stationarity of the Golgi structures and the constant streaming of membrane traffic. A combinational model of both categories was used for computational reconstruction of the de novo Golgi formation process, which might provide an insight into the integrated understanding of the Golgi structure.
真核细胞将其膜折叠成高度组织化的结构，称为膜结合细胞器。细胞器显示出与其结构相关的特征结构和专门功能。本文聚焦于高尔基体，提供了对最近理论研究的概述，以解释高尔基体结构的机制。这些研究分为两类：一类使用平衡模型来描述坚固的高尔基体形态，另一类使用非平衡模型来解释高尔基体结构的稳定性和膜运输的恒定流动。这两类的组合模型用于从头开始的高尔基体形成过程的计算重建，这可能为高尔基体结构的综合理解提供一个视角。
