Vivien J N, Leperchey F, Vicaut E, Deplus S, Gervais P
Centre Edouard-Rist, Paris.
Rev Mal Respir. 1987;4(4):173-6.
In a group of 153 white subjects treated for tubercle, individual determinations were made of: a) The power of inactivation of isoniazid. b) The degree of pigmentation (iris, skin, hair) assessed by a weighted pigmented index of the iris. A statistical study of the results shows the clear existence of a narrow positive correlation between these two characters, such that the more pigmented a subject is, the greater is the chance of rapid inactivation of isoniazid. An attempt at a biochemical explanation is proposed. The results in the world literature (Japanese, Swedish, American) are in keeping with these observations. Thus, weakly pigmented tuberculous patients are potentially a new group at risk from anti-TB drugs.
在一组接受结核治疗的153名白人受试者中，对以下各项进行了个体测定：a）异烟肼的灭活能力。b）通过虹膜加权色素沉着指数评估的色素沉着程度（虹膜、皮肤、毛发）。对结果的统计研究表明，这两个特征之间明显存在微弱的正相关，即受试者色素沉着越多，异烟肼快速灭活的可能性就越大。本文提出了一种生化解释。世界文献（日本、瑞典、美国）中的结果与这些观察结果一致。因此，色素沉着较弱的结核病患者可能是抗结核药物的一个新的风险群体。
