Leperchey F, Vivien J N, Vicaut E, Galliot M, Deplus S, Gervais P
Int J Clin Pharmacol Res. 1985;5(4):283-6.
A positive correlation has been observed clinically at the Centre Edouard Rist, Paris, between the degree of pigmentation and the power of isoniazid acetylation in so-called "caucasians". The investigation was based on a relatively small sample of 153 observations, but sufficient to allow a significant statistical analysis. Comparing the results with data published in the literature, it may be assumed that this relationship between the power of acetylation and pigmentation would be applicable to all human beings. The rabbit, having as in man a bi-modal distribution of the power of acetylation, was used for further research of this correlation in that animal. The results of this research in rabbits may be compared with those in man, but further studies are required in view of the interest of this comparison and of the possible consequences of the relationship of pigmentation and the degree of acetylation of isoniazid in human therapeutics.
在巴黎的爱德华·里斯特中心，临床上已观察到在所谓的“白种人”中，色素沉着程度与异烟肼乙酰化能力之间存在正相关。该调查基于相对较小的153例观察样本，但足以进行有意义的统计分析。将结果与文献中发表的数据进行比较，可以假设乙酰化能力与色素沉着之间的这种关系适用于所有人。兔子与人一样具有乙酰化能力的双峰分布，因此被用于进一步研究该动物体内的这种相关性。兔子的这项研究结果可与人类的结果进行比较，但鉴于这种比较的意义以及色素沉着与异烟肼乙酰化程度之间的关系在人类治疗中的可能后果，还需要进一步研究。
