人类免疫缺陷病毒未得到控制的人群中严重的猴痘感染。
Severe Mpox Infections in People With Uncontrolled Human Immunodeficiency Virus.
机构信息
Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Parkland Health, Dallas, Texas, USA.
出版信息
Clin Infect Dis. 2023 May 24;76(10):1843-1846. doi: 10.1093/cid/ciad052.
In the current mpox outbreak, infections are usually self-limited. We describe 3 patients with uncontrolled HIV and mpox infections lasting months, causing debilitating lesions, complications, and death, despite initiating anti-mpox and antiretroviral therapy. Delayed treatment of mpox with antiviral agents may contribute to poor outcomes in severely immunocompromised patients.
在当前的猴痘疫情中，感染通常是自限性的。我们描述了 3 例 HIV 未得到控制且猴痘感染持续数月的患者，尽管开始了抗猴痘和抗逆转录病毒治疗，但仍导致严重的皮损、并发症和死亡。在严重免疫功能低下的患者中，抗病毒药物治疗猴痘的延迟可能导致不良结局。
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