纽约市接受长期替考韦瑞玛治疗的晚期人类免疫缺陷病毒感染者中的严重猴痘病例
Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City.
作者信息
Garcia Elizabeth A, Foote Mary M K, McPherson Tristan D, Lash Maura K, Bosompem Amma N, Bouscaren Alyssa, Chan Justin, DiLorenzo Madeline A, Feihel Dennis, Fowler Randal C, Gandhi Vani, Jenny-Avital Elizabeth R, Kopping Erik J, Mazo Dana, McLean Jacob, Mgbako Ofole, Sayegh Mark N, Shaw Raphael N, Su Michelle, Meissner Jeanne Sullivan, Wang Jade C, Wen Wendy, Winters John C, Zeana Cosmina B, Zucker Jason, Wong Marcia
机构信息
Division of Disease Control, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Human Resources Administration, New York City Department of Social Services, New York, New York, USA.
出版信息
Open Forum Infect Dis. 2024 May 17;11(6):ofae294. doi: 10.1093/ofid/ofae294. eCollection 2024 Jun.
Severe mpox has been observed in people with advanced human immunodeficiency virus (HIV). We describe clinical outcomes of 13 patients with advanced HIV (CD4 <200 cells/μL), severe mpox, and multiorgan involvement. Despite extended tecovirimat courses and additional agents, including vaccinia immune globulin, cidofovir, and brincidofovir, this group experienced prolonged hospitalizations and high mortality.
在晚期人类免疫缺陷病毒（HIV）感染者中观察到了严重的猴痘病例。我们描述了13例晚期HIV感染者（CD4细胞计数<200个/μL）、严重猴痘且伴有多器官受累患者的临床结局。尽管接受了延长疗程的特考韦瑞治疗以及包括牛痘免疫球蛋白、西多福韦和布瑞西多福韦在内的其他药物治疗，但该组患者住院时间延长且死亡率较高。
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