帕金森病中与圣诞节相关的β活动减少。
Christmas-Related Reduction in Beta Activity in Parkinson's Disease.
机构信息
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
出版信息
Mov Disord. 2023 Apr;38(4):692-697. doi: 10.1002/mds.29334. Epub 2023 Jan 31.
BACKGROUND
Subthalamic nucleus (STN) beta (13 - 35 Hz) activity is a biomarker reflecting motor state in Parkinson's disease (PD). Adaptive deep brain stimulation (DBS) aims to use beta activity for therapeutic adjustments, but many aspects of beta activity in real-life situations are unknown.
OBJECTIVE
The aim was to investigate Christmas-related influences on beta activity in PD.
METHODS
Differences in Christmas Day to nonfestive daily averages in chronic biomarker recordings in 4 PD patients with a sensing-enabled STN DBS implant were retrospectively analyzed. Sweet-spot and whole-brain network connectomic analyses were performed.
RESULTS
Beta activity was significantly reduced on Christmas Eve in all patients (4.00-9.00 p.m.: -12.30 ± 10.78%, P = 0.015). A sweet spot in the dorsolateral STN connected recording sites to motor, premotor, and supplementary motor cortices.
CONCLUSIONS
We demonstrate that festive events can reduce beta biomarker activity. We conclude that circadian and holiday-related changes should be considered when tailoring adaptive DBS algorithms to patient demands. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
背景
丘脑底核（STN）β（13-35Hz）活动是反映帕金森病（PD）运动状态的生物标志物。适应性脑深部刺激（DBS）旨在利用β活动进行治疗调整，但现实生活中β活动的许多方面尚不清楚。
目的
研究与圣诞节相关的因素对 PD 中β活动的影响。
方法
回顾性分析 4 名接受 STN DBS 植入且具有感应功能的 PD 患者慢性生物标志物记录中圣诞节当天与非节日日常平均值的差异。进行了热点和全脑网络连接组学分析。
结果
所有患者在平安夜β活动均显著降低（4.00-9.00pm：-12.30±10.78%，P=0.015）。STN 背外侧的一个热点将记录点与运动、运动前和辅助运动皮质连接起来。
结论
我们证明了节日活动可以降低β生物标志物的活性。我们得出结论，在根据患者需求定制适应性 DBS 算法时，应考虑昼夜节律和节假日相关的变化。
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