Springate J, Jeffery D, Acara M
Department of Pediatrics, Childrens Hospital, Buffalo, New York 14222.
Res Commun Chem Pathol Pharmacol. 1987 Sep;57(3):343-50.
The effects of prednisolone on renal tubular transport of organic ions, urine flow and glomerular filtration rate were studied using the Sperber preparation in chickens. Low infusion rates of 1 and 5 nmole/min prednisolone slightly enhanced organic ion excretion. At higher infusion rates up to 1,000 nmol/min, no change in organic ion transport was observed. Urine flow and glomerular filtration rate increased at prednisolone infusion rates of 50 nmole/min and higher, independent of changes in renal blood flow.
使用鸡的斯珀伯（Sperber）制备模型研究了泼尼松龙对鸡肾小管有机离子转运、尿流和肾小球滤过率的影响。泼尼松龙以1和5纳摩尔/分钟的低输注速率时，可轻微增强有机离子排泄。在高达1000纳摩尔/分钟的较高输注速率下，未观察到有机离子转运有变化。当泼尼松龙输注速率为50纳摩尔/分钟及更高时，尿流和肾小球滤过率增加，且与肾血流量的变化无关。
