[Influence of intravenous steroid administration on kidney function].

The acute renal response to 1,0 g Prednisolon i.v. in kidney transplant recipients and normal controls was investigated. The results indicate an acute suppression of glomerular filtration rate (CIN, CCR) and effective plasma flow (CPAH). The reabsorption of sodium in the proximal tubule was shown to be impaired as a direct effect of the steroid infusion, as well as there was an increase in the filtered fraction of potassium. The creatinine clearance under treatment of high doses of steroids does not reflect the actual changes in glomerular filtration rate