Wilke A, Müller B, von Wichert P
Medizinische Poliklinik der Philipps-Universität, Klinikum Lahnberge, Marburg, FRG.
Respiration. 1987;52(2):129-36. doi: 10.1159/000195315.
Ambroxol, a drug capable of elevating the phospholipid content in healthy rabbit lungs, was tested on two models of experimental lung injury, lung changes in sepsis induced by a peritonitis and in bromcarbamide intoxication. The phospholipid content of the lungs and the synthesis of the individual phospholipids phosphatidylcholine (PC) and sphingomyeline were measured in vitro by incubation of lung slices with labeled phospholipid precursors. Influenced by the drug, the phospholipid content increases to 132% in the peritonitis experiments and to 111% in the bromcarbamide experiments. The peritonitis experiments show the increase in phospholipid synthesis to result from an enhanced choline incorporation into PC up to 192% and into sphingomyeline up to 630%. The values for the bromcarbamide experiments are 411% for PC and 485% for sphingomyeline, respectively. There was no statistically significant difference in the incorporation of fatty acids in the treated and untreated animals. We conclude that ambroxol possibly stimulates the phospholipid synthesis in injured lungs by stimulating the choline phosphatcytidyltransferase, but not the incorporation of fatty acids into PC in those lungs. These findings may be important to the surfactant system of the lung consisting mainly of PC.
氨溴索是一种能够提高健康兔肺磷脂含量的药物，在两种实验性肺损伤模型上进行了测试，即腹膜炎诱导的脓毒症和溴卡胺中毒引起的肺变化。通过用标记的磷脂前体孵育肺切片，在体外测量肺的磷脂含量以及个别磷脂磷脂酰胆碱（PC）和鞘磷脂的合成。受该药物影响，在腹膜炎实验中磷脂含量增加到132%，在溴卡胺实验中增加到111%。腹膜炎实验表明，磷脂合成增加是由于胆碱掺入PC增加至192%，掺入鞘磷脂增加至630%。溴卡胺实验中PC和鞘磷脂的值分别为411%和485%。在治疗组和未治疗组动物中，脂肪酸掺入量没有统计学上的显著差异。我们得出结论，氨溴索可能通过刺激胆碱磷酸胞苷转移酶来刺激受损肺中的磷脂合成，但不刺激脂肪酸掺入这些肺中的PC。这些发现可能对主要由PC组成的肺表面活性物质系统很重要。
