Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
J Surg Oncol. 2023 Apr;127(5):882-890. doi: 10.1002/jso.27204. Epub 2023 Jan 31.
Asian Americans, Native Hawaiians, and Pacific Islanders (AANHPI) represent the fastest-growing group in the United States. While described in aggregate, great variations exist within the community. We aimed to determine whether there were differences in stage at presentation and treatment status among AANHPI women with non-small cell lung cancer (NSCLC).
Between 2004 and 2016, we identified 522 361 female patients with newly diagnosed NSCLC from the National Cancer Database. Multivariable logistic regression models were used to define adjusted odds ratios (aORs) of presenting with stage IV disease and not receiving treatment.
AANHPI women were more likely to present with stage IV disease compared to White (54.32% vs. 40.28%, p < 0.001). Aside from Hawaiian, Pakistani, and Hmong women, all other ethnic groups had greater odds of presenting with stage IV disease than White women. AANHPI women <65 years were more likely to present with stage IV disease (p = 0.030). Only Vietnamese women showed a significant difference (aOR = 1.30 [1.06-1.58], p = 0.010) for likelihood of receiving treatment compared to White.
Differences in stage at presentation and treatment status in women with NSCLC were observed among AANHPI ethnic groups when populations were disaggregated.
亚裔美国人、夏威夷原住民和太平洋岛民（AANHPI）是美国增长最快的群体。尽管他们被整体描述，但社区内部存在很大差异。我们旨在确定非小细胞肺癌（NSCLC）AANHPI 女性患者在就诊时的分期和治疗状况是否存在差异。
在 2004 年至 2016 年期间，我们从国家癌症数据库中确定了 522361 名新诊断为 NSCLC 的女性患者。多变量逻辑回归模型用于定义患有 IV 期疾病和未接受治疗的调整后优势比（aOR）。
与白人女性相比（54.32% vs. 40.28%，p<0.001），AANHPI 女性更有可能出现 IV 期疾病。除了夏威夷、巴基斯坦和苗族女性外，所有其他族裔群体出现 IV 期疾病的几率都高于白人女性。<65 岁的 AANHPI 女性更有可能出现 IV 期疾病（p=0.030）。只有越南女性在接受治疗的可能性方面表现出显著差异（aOR=1.30[1.06-1.58]，p=0.010）。
当人群细分时，NSCLC 女性中 AANHPI 族裔群体在就诊时的分期和治疗状况存在差异。
