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The inhibition of PARG attenuates DNA repair in hepatocellular carcinoma.

作者信息

Geng Longpo, Sun Yaling, Zhu Mingming, An Hongda, Li Yunzheng, Lao Yuanxiang, Zhang Yongli, Li Binghua, Ni Jie, Xu Zhu

机构信息

Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Department of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.

出版信息

Mol Biomed. 2023 Jan 31;4(1):3. doi: 10.1186/s43556-023-00114-6.

DOI:10.1186/s43556-023-00114-6
PMID:36719492
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9889579/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7828/9889579/9c3f52e0a628/43556_2023_114_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7828/9889579/9c3f52e0a628/43556_2023_114_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7828/9889579/9c3f52e0a628/43556_2023_114_Fig1_HTML.jpg

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The inhibition of PARG attenuates DNA repair in hepatocellular carcinoma.PARG的抑制作用会减弱肝细胞癌中的DNA修复。
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2
Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis.聚(ADP-核糖)糖水解酶(PARG)的核同工型缺失揭示了其在 DNA 修复、基因组稳定性和肿瘤发生中的作用。
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PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.PARG 和 BRCA1-BARD1 协同功能调控配子发生过程中 DNA 修复途径的选择。
Nucleic Acids Res. 2022 Nov 28;50(21):12291-12308. doi: 10.1093/nar/gkac1153.
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PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models.PARP抑制作用以及PARP抑制剂ABT - 888在体外肝癌模型中的放射增敏作用。
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PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.PARG通过多聚(ADP-核糖)和PCNA依赖的机制被招募到DNA损伤位点。
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本文引用的文献

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PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy.聚(ADP - 核糖)糖苷酶(PARG)抑制作用可限制肝癌进展并增强免疫检查点疗法的疗效。
J Hepatol. 2022 Jul;77(1):140-151. doi: 10.1016/j.jhep.2022.01.026. Epub 2022 Feb 12.
2
Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies.靶向去 PAR 化选择性抑制 DNA 修复缺陷和 PARP 抑制剂耐药的恶性肿瘤。
Sci Adv. 2019 Apr 10;5(4):eaav4340. doi: 10.1126/sciadv.aav4340. eCollection 2019 Apr.
3
Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors.
Mol Biomed. 2024 Oct 17;5(1):49. doi: 10.1186/s43556-024-00209-8.
4
TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma.TKT-PARP1 轴通过促进肝癌中 DNA 双链断裂修复诱导放射抵抗。
Oncogene. 2024 Feb;43(9):682-692. doi: 10.1038/s41388-023-02935-9. Epub 2024 Jan 12.
超分辨率成像技术鉴定出 PARP1 和 Ku 复合物作为 DNA 双链断裂传感器。
Nucleic Acids Res. 2018 Apr 20;46(7):3446-3457. doi: 10.1093/nar/gky088.
4
PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.PARP1驱动的多聚ADP核糖基化在同源重组介导的DNA修复中调节BRCA1功能。
Cancer Discov. 2014 Dec;4(12):1430-47. doi: 10.1158/2159-8290.CD-13-0891. Epub 2014 Sep 24.
5
PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.PARG通过多聚(ADP-核糖)和PCNA依赖的机制被招募到DNA损伤位点。
Nucleic Acids Res. 2011 Jul;39(12):5045-56. doi: 10.1093/nar/gkr099. Epub 2011 Mar 11.