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菲律宾一家三级医院 HIV 关怀链的描述性回顾性研究。

A descriptive retrospective study on HIV care cascade in a tertiary hospital in the Philippines.

机构信息

Division of Infectious Diseases, Department of Medicine, University of the Philippines-Philippine General Hospital, Manila, Philippines.

出版信息

PLoS One. 2023 Jan 31;18(1):e0281104. doi: 10.1371/journal.pone.0281104. eCollection 2023.

Abstract

INTRODUCTION

The HIV care cascade is a model used to examine the engagement of people living with HIV (PLHIV) in medical care from the time of diagnosis to sustained viral suppression. This study describes the stages of the cascade from linkage to care, antiretroviral therapy (ART) initiation, retention in care, and virologic suppression- at the University of the Philippines-Philippine General Hospital (UP-PGH) STD/AIDS Guidance and Intervention Prevention (SAGIP) treatment hub in the context of existing cascades with similar demographics.

METHODS

We retrospectively reviewed the medical records of patients enrolled at the UP-PGH SAGIP treatment hub from June 2015 to December 2017. Baseline demographic and clinical data were collected, relevant to each stage of the cascade. Descriptive statistics using Microsoft Excel version 16.0 was used to characterize data and cumulative and conditional proportions were reported.

RESULTS

Of the 584 patients included in the cohort, majority were male (91.1%), with a median age of 29 years (range, 0.17 to 68 years). Male-to-male sex was the most common mode of transmission (325/584, 55.6%). Among all patients enrolled at the UP PGH SAGIP treatment hub, 99.5% were linked to care, 95.0% initiated ART, 78.8% were retained in care and maintained on ART, 47.9% were tested for HIV viral load, and 45.5% achieved viral suppression.

CONCLUSION

A high proportion of patients enrolled at the UP-PGH SAGIP treatment hub are linked to care and initiate ART, exceeding the set goal of 90%, which is higher than reported nationwide. However, there is a substantial decrease in the number of patients who are subsequently retained in care, tested for HIV viral load, and achieve viral suppression. Gaps in the cascade related to healthcare delivery need to be investigated further and addressed by future studies. We recommend implementation of a community-based, patient-centered approach in order to reach the goals of the HIV cascade, with particular focus on young, MSM-PLHIV.

摘要

简介

HIV 关怀链是一种用于检查艾滋病毒感染者(PLHIV)从诊断到持续病毒抑制的医疗保健参与度的模型。本研究描述了在菲律宾大学菲律宾总医院(UP-PGH)STD/AIDS 指导和干预预防(SAGIP)治疗中心的关怀链中的各个阶段,包括从联系到关怀、开始抗逆转录病毒治疗(ART)、在关怀中保留以及病毒学抑制 - 在具有类似人口统计学特征的现有关怀链的背景下。

方法

我们回顾性地审查了 2015 年 6 月至 2017 年 12 月期间在 UP-PGH SAGIP 治疗中心登记的患者的病历。收集了与关怀链的各个阶段相关的基线人口统计学和临床数据。使用 Microsoft Excel 版本 16.0 进行描述性统计,以描述数据,并报告累积和条件比例。

结果

在纳入的 584 名患者队列中,大多数为男性(91.1%),中位年龄为 29 岁(范围为 0.17 至 68 岁)。男男性行为是最常见的传播途径(325/584,55.6%)。在所有在 UP PGH SAGIP 治疗中心登记的患者中,99.5%的患者与关怀链联系,95.0%的患者开始接受 ART,78.8%的患者在关怀中保留并维持接受 ART,47.9%的患者接受了 HIV 病毒载量检测,45.5%的患者实现了病毒抑制。

结论

在 UP-PGH SAGIP 治疗中心登记的患者中有很大一部分与关怀链联系并开始接受 ART,超过了设定的 90%的目标,这高于全国报告的水平。然而,随后在关怀中保留、接受 HIV 病毒载量检测和实现病毒抑制的患者数量大幅减少。需要进一步调查与医疗保健提供相关的关怀链中的差距,并由未来的研究加以解决。我们建议实施以社区为基础、以患者为中心的方法,以实现 HIV 关怀链的目标,特别关注年轻的男男性行为者 HIV 感染者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ae/9888700/0e14e52d78ee/pone.0281104.g001.jpg

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