Narii Nobuhiro, Zha Ling, Sobue Tomotaka, Kitamura Tetsuhisa, Shiba Satoshi, Mizutani Sayaka, Yamada Takuji, Yachida Shinichi
Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Division of Genomic Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Cancer Prev Res (Phila). 2023 Jan 30:OF1-OF8. doi: 10.1158/1940-6207.CAPR-22-0399.
Fusobacterium nucleatum is involved in the development and progression of colorectal cancer. Although the gut microbiota is influenced by diet, studies on the association between diet and F. nucleatum are limited. We aimed to evaluate the association between various dietary factors and fecal F. nucleatum in healthy adults without a history of colorectal cancer or precancerous lesions. This was a cross-sectional study. Subjects who underwent total colonoscopy at the National Cancer Center Hospital (Tokyo, Japan) were included. Healthy subjects (n = 212) were divided into two groups according to the presence or absence of F. nucleatum in their feces which was calculated from data of whole-genome shotgun sequencing, with the group with F. nucleatum serving as cases and the group without F. nucleatum serving as controls. Multivariable logistic regression analysis adjusted potential confounders was conducted to estimate the associations between dietary intake and nutrients estimated by a validated food frequency questionnaire and the presence of F. nucleatum in the feces. There was a significant inverse association between dairy products and the presence of fecal F. nucleatum [high vs. low; OR, 0.41; 95% confidence interval, 0.17-0.95; Ptrend, 0.039]. These results may have important implications for colorectal cancer prevention through nutritional intervention.
F. nucleatum is well known as a colorectal cancer-associated bacterium. Dietary habits alter the composition and function of the intestinal microbiota. A high intake of dairy products in healthy adults may reduce F. nucleatum and prevent colorectal cancer.
具核梭杆菌参与结直肠癌的发生和发展。尽管肠道微生物群会受到饮食的影响，但关于饮食与具核梭杆菌之间关联的研究有限。我们旨在评估各种饮食因素与无结直肠癌或癌前病变病史的健康成年人粪便中具核梭杆菌之间的关联。这是一项横断面研究。纳入了在日本东京国立癌症中心医院接受全结肠镜检查的受试者。根据全基因组鸟枪法测序数据计算出的粪便中是否存在具核梭杆菌，将健康受试者（n = 212）分为两组，具核梭杆菌组作为病例组，无具核梭杆菌组作为对照组。进行多变量逻辑回归分析以调整潜在混杂因素，从而估计通过经验证的食物频率问卷评估的饮食摄入量和营养素与粪便中具核梭杆菌存在之间的关联。乳制品与粪便中具核梭杆菌的存在之间存在显著的负相关[高摄入量与低摄入量相比；比值比，0.41；95%置信区间，0.17 - 0.95；趋势P值，0.039]。这些结果可能对通过营养干预预防结直肠癌具有重要意义。
具核梭杆菌是一种众所周知的与结直肠癌相关的细菌。饮食习惯会改变肠道微生物群的组成和功能。健康成年人高摄入乳制品可能会减少具核梭杆菌并预防结直肠癌。
