Lowe G D
West of Scotland Haemophilia Reference Centre.
Scott Med J. 1987 Aug;32(4):109-11. doi: 10.1177/003693308703200404.
Between 1979 and 1984, many haemophiliacs in the UK were exposed to the human immunodeficiency virus (HIV) by transfusion of blood products, in particular clotting factor concentrates, especially those imported from the USA. In the UK 1025 haemophiliacs are HIV-antibody-positive, of whom 75 are in Scotland. Thirty-one UK haemophiliacs have developed the Acquired Immune Deficiency Syndrome (AIDS), of whom 23 have died. The clinical progress of HIV infection appears similar in haemophiliacs and in other risk groups, except that Kaposi's sarcoma is rare. There is evidence that transfusion of blood products is immunosuppressive in the absence of HIV antibody. Blood donor selection and heat treatment of clotting factor concentrates were introduced from 1985, and so far these measures appear to have largely prevented new HIV infection in haemophiliacs. Meanwhile a tragic toll of iatrogenic disease and death continues to increase.
1979年至1984年间，英国许多血友病患者因输血制品，尤其是凝血因子浓缩物，接触到了人类免疫缺陷病毒（HIV），这些凝血因子浓缩物尤其那些从美国进口的。在英国，1025名血友病患者HIV抗体呈阳性，其中75人在苏格兰。31名英国血友病患者已发展为获得性免疫缺陷综合征（AIDS），其中23人已经死亡。除了卡波西肉瘤罕见外，HIV感染在血友病患者和其他风险群体中的临床进展似乎相似。有证据表明，在没有HIV抗体的情况下，输血制品具有免疫抑制作用。从1985年开始实施献血者筛选和凝血因子浓缩物的热处理，到目前为止，这些措施似乎在很大程度上预防了血友病患者感染新的HIV。与此同时，医源性疾病和死亡的悲惨代价仍在不断增加。
