Waskell L
Anesthesiology. 1979 Jan;50(1):9-12. doi: 10.1097/00000542-197901000-00003.
1,1-Difluoro-2-bromo-2-chloroethylene, a probable metabolite of halothane, was purified by preparative gas chromatography and tested for mutagenicity in the Salmonella/mammalian liver system developed by Ames and colleagues. 1,1,1-Trifluoro-2-chloroethane which had been isolated from the breath or rabbits anesthetized with halothane was also tested for mutagenicity in a similar manner. Both compounds were found to be nonmutagenic in this bacterial system. Although neither this study nor any other has yet been able to demonstrate that halothane or any of its metabolites is genetically active, nevertheless, unnecessary occupational exposure to the drug should be avoided due to the possibility that future studies could reveal adverse effects secondary to halothane.
1,1 - 二氟 - 2 - 溴 - 2 - 氯乙烯是氟烷的一种可能代谢产物，通过制备气相色谱法进行纯化，并在由艾姆斯及其同事开发的沙门氏菌/哺乳动物肝脏系统中测试其致突变性。从用氟烷麻醉的兔子呼出气体中分离出的1,1,1 - 三氟 - 2 - 氯乙烷也以类似方式测试其致突变性。在该细菌系统中发现这两种化合物均无致突变性。尽管这项研究和其他任何研究都尚未能够证明氟烷或其任何代谢产物具有遗传活性，然而，由于未来的研究可能揭示氟烷继发的不良反应，应避免不必要的职业接触该药物。
