Department of Pediatrics, CHU de Nantes, Nantes, France.
Department of Pediatric Endocrinology, CHU de Nantes, Nantes, France.
Endocrinol Diabetes Metab. 2023 Mar;6(2):e389. doi: 10.1002/edm2.389. Epub 2023 Feb 1.
Hyperglycaemic hyperosmolar state (HHS) is a known complication of type 2 diabetes mellitus; however, carbonated carbohydrate fluid intake may precipitate a more severe presentation of type 1 diabetes mellitus with hyperosmolar state. The management of these patients is not easy and can lead to severe complications such as cerebral venous thrombosis.
We present the case of a 21-month-old boy admitted for consciousness disorders revealing a hyperglycaemic hyperosmolar state on a new-onset type 1 diabetes and who developed cerebral venous thrombosis.
Emergency physicians should be aware of HHS in order to start the appropriate treatment as early as possible and to monitor the potential associated acute complications. This case highlights the importance of decreasing very gradually the osmolarity in order to avoid cerebral complications. Cerebral venous thrombosis in HHS paediatric patients is rarely described, and it is important to recognize that not all episodes of acute neurological deterioration in HHS or diabetic ketoacidosis are caused by cerebral oedema.
高血糖高渗状态(HHS)是 2 型糖尿病的已知并发症;然而,碳酸碳水化合物的摄入可能会使 1 型糖尿病伴高渗状态的表现更为严重。这些患者的治疗并不容易,可能会导致严重的并发症,如脑静脉血栓形成。
我们报告了一例 21 个月大的男孩,因意识障碍入院,新发 1 型糖尿病合并高血糖高渗状态,并发脑静脉血栓形成。
急诊医生应该意识到 HHS 的存在,以便尽早开始适当的治疗,并监测潜在的相关急性并发症。本病例强调了逐渐降低渗透压以避免脑并发症的重要性。HHS 儿科患者的脑静脉血栓形成很少见,重要的是要认识到并非所有 HHS 或糖尿病酮症酸中毒的急性神经功能恶化都是由脑水肿引起的。