State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Nanoscale. 2023 Feb 16;15(7):3188-3198. doi: 10.1039/d2nr06224k.
Multifunctional nanoplatforms with the synergistic effects of multiple therapeutic modalities have become a research focus due to their superior anti-tumor properties over single therapeutic modalities. Herein, we developed around 14 nm porous hollow copper iron oxide nanoparticles (PHCuFeNPs) with pore sizes of around 2-3 nm as a cisplatin carrier and photothermal therapeutic agent. The PHCuFeNPs were synthesized a galvanic reaction between CuS nanoparticles and iron pentacarbonyl (Fe(CO)) followed by etching in the organic phase to make the pores. They were stable under normal physiological conditions, but the pores were etched in a weak acidic tumor microenvironment, resulting in the controlled release of Cu and Fe ions for enhanced chemodynamic therapy and accelerated cisplatin release for chemotherapy. Under 980 nm laser irradiation, the PHCuFeNPs could effectively heat up to further promote the release process for synergistic therapy. Besides, they were proved to mediate immunogenic cell death to activate the immune system for potential immunotherapy. Together with their ability to degrade into fragments for fast renal metabolism, we believe that these PHCuFeNPs could provide a biocompatible and efficient multi-antitumor therapeutic approach.
多功能纳米平台具有多种治疗模式的协同效应，由于其抗肿瘤性能优于单一治疗模式，因此成为研究热点。在此，我们开发了具有约 2-3nm 孔径的多孔空心氧化铜铁纳米颗粒（PHCuFeNPs）作为顺铂载体和光热治疗剂。PHCuFeNPs 通过 CuS 纳米颗粒和五羰基铁（Fe(CO)）之间的电偶反应合成，然后在有机相中进行蚀刻以产生孔。它们在正常生理条件下稳定，但在弱酸性肿瘤微环境中，孔被蚀刻，导致 Cu 和 Fe 离子的受控释放，以增强化学动力学治疗并加速顺铂释放进行化疗。在 980nm 激光照射下，PHCuFeNPs 能够有效升温，以进一步促进协同治疗的释放过程。此外，它们被证明可以介导免疫原性细胞死亡以激活免疫系统，用于潜在的免疫治疗。结合其能够降解为碎片进行快速肾脏代谢的能力，我们相信这些 PHCuFeNPs 可以提供一种具有生物相容性和高效的多抗肿瘤治疗方法。
