Becker W, Konstantinides F, Eyer S, Ward H, Fath J, Cerra F
Department of Surgery, University of Minnesota, Minneapolis.
Surgery. 1987 Nov;102(5):777-83.
A major function of the liver is to maintain normal levels of plasma amino acids. This function may depend in part on tissue levels of high-energy phosphate. Experiments were performed in adult mongrel dogs to assess the relationship between plasma amino acid clearance (PAAC) and tissue high-energy phosphate after 90 minutes of warm hepatic ischemia. In addition, when PAAC was assessed in the anhepatic dog, PAAC fell to low levels after hepatectomy. After 90 minutes of warm ischemia, both tissue adenosine triphosphate (ATP) and PAAC fell to low levels, with PAAC similar to those levels observed in anhepatic dogs. Recovery of ATP and PAAC progressed over a 48-hour period but did not reach control values. Mortality rate was 33% in a group of 12 animals at 48 hours after ischemia. At 24 hours after ischemia, total free plasma amino acid levels were significantly higher in those animals that were dying as compared with those that were surviving (4352 mumol/L versus 2850 mumol/L; p less than 0.05). There was a strong correlation between PAAC and ATP (r = 0.81). PAAC appears to be an indicator of hepatic functional recovery and tissue ATP levels after ischemia.
肝脏的一项主要功能是维持血浆氨基酸的正常水平。该功能可能部分取决于高能磷酸的组织水平。在成年杂种狗身上进行了实验，以评估90分钟热缺血后血浆氨基酸清除率（PAAC）与组织高能磷酸之间的关系。此外，在无肝狗身上评估PAAC时，肝切除术后PAAC降至低水平。热缺血90分钟后，组织三磷酸腺苷（ATP）和PAAC均降至低水平，PAAC与在无肝狗身上观察到的水平相似。ATP和PAAC的恢复在48小时内进行，但未达到对照值。在一组12只动物中，缺血后48小时的死亡率为33%。缺血后24小时，濒死动物的血浆总游离氨基酸水平显著高于存活动物（4352μmol/L对2850μmol/L；p<0.05）。PAAC与ATP之间存在很强的相关性（r = 0.81）。PAAC似乎是缺血后肝功能恢复和组织ATP水平的一个指标。
