18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在一例抗γ-氨基丁酸B型受体副肿瘤性边缘叶脑炎中的肿瘤及神经治疗反应

18FDG PET/CT Tumoral and Neurologic Therapeutic Response in a Case of Anti-GABABR Paraneoplastic Limbic Encephalitis.

作者信息

Ouvrard Eric, Voulleminot Paul, Mennecier Bertrand, Bund Caroline, Namer Izzie Jacques

机构信息

From the Service de Médecine Nucléaire et Imagerie Moléculaire, Institut de Cancérologie Strasbourg Europe (ICANS).

Service de Neurologie.

出版信息

Clin Nucl Med. 2023 Mar 1;48(3):237-239. doi: 10.1097/RLU.0000000000004552. Epub 2023 Jan 20.

DOI:10.1097/RLU.0000000000004552

PMID:36723883

Abstract

A 70-year-old man with a history of small cell lung carcinoma 2 years earlier was addressed for the suspicion of a paraneoplastic limbic encephalitis. Brain 18FDG PET/CT revealed a bilateral amygdalian and hippocampal hypermetabolism, confirming a limbic encephalitis, and concurrent whole-body 18FDG PET/CT showed a small cell lung carcinoma plurifocal metastatic recurrence, consistent with a paraneoplastic limbic encephalitis. 18FDG PET/CT follow-up under chemotherapy revealed an almost complete normalization of brain metabolism and a partial metabolic response of the metastatic recurrence, consistent with the good clinical neurological evolution of the patient. This case highlights the clinical-metabolic imaging correlation in paraneoplastic limbic encephalitis.

摘要

一名70岁男性，两年前有小细胞肺癌病史，因疑似副肿瘤性边缘叶脑炎前来就诊。脑部18FDG PET/CT显示双侧杏仁核和海马体代谢增高，确诊为边缘叶脑炎，同时全身18FDG PET/CT显示小细胞肺癌多灶性转移复发，符合副肿瘤性边缘叶脑炎。化疗期间的18FDG PET/CT随访显示脑部代谢几乎完全恢复正常，转移复发灶有部分代谢反应，与患者良好的临床神经学进展相符。该病例突出了副肿瘤性边缘叶脑炎中临床与代谢成像的相关性。