18F-FDG PET/CT检查发现的小细胞肺癌继发副肿瘤性边缘叶脑炎

Paraneoplastic Limbic Encephalitis Secondary to SCLC on 18F-FDG PET/CT.

作者信息

Verçosa Alinne Fernanda Amaral, Mota Isabella Araújo, Flamini Maria Eduarda Duarte de Mello, Flamini Rodrigo de Carvalho

机构信息

From the Nuclear Medicine Department, NOVA Diagnóstico por Imagem.

Neurology Department, Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa.

出版信息

Clin Nucl Med. 2021 Jun 1;46(6):494-496. doi: 10.1097/RLU.0000000000003628.

DOI:10.1097/RLU.0000000000003628

PMID:33939650

Abstract

A 67-year-old man with rapidly neurologic deterioration and 15 kg weight loss in 2 months was extensively evaluated by several medical specialties and conventional image examinations, with no diagnostic definition. 18F-FDG PET/CT was performed, showing glycolytic hypermetabolism in the hippocampus, cerebral hypometabolism with posterior temporoparietal pattern, multiple cervical and supraclavicular lymph nodes, and mediastinal hypermetabolic and enlarged lymph nodes, suggesting paraneoplastic limbic encephalitis, Alzheimer dementia, and lymphoma. Lymph node biopsy resulted in small cell lung carcinoma. The patient presented rapid clinical deterioration and died.

摘要

一名67岁男性，在2个月内出现快速的神经功能恶化并体重减轻15千克，多个医学专科和传统影像检查对其进行了全面评估，但未明确诊断。进行了18F-FDG PET/CT检查，结果显示海马区糖酵解代谢增高、颞顶叶后部模式的大脑代谢减低、多个颈部和锁骨上淋巴结以及纵隔代谢增高且肿大的淋巴结，提示副肿瘤性边缘叶脑炎、阿尔茨海默病性痴呆和淋巴瘤。淋巴结活检结果为小细胞肺癌。该患者临床病情迅速恶化并死亡。