Khan Nawal, Halaseh Faris F, Pillai Kathryn, Zaki Daniel P, Sayadi Lohrasb R, Widgerow Alan D
Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, US.
J Wound Care. 2023 Feb 2;32(Sup2):S20-S30. doi: 10.12968/jowc.2023.32.Sup2.S20.
This review aims to evaluate the effectiveness of the two most commonly used oxygen delivery methods for the treatment of thermal burn wound healing: hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT).
The PubMed database was searched for articles discussing the use of HBOT or TOT in the treatment of thermal burns.
The search yielded 43,406 articles, of which 28 (23 HBOT, 5 TOT) met the inclusion criteria. Both experimental and clinical studies have demonstrated conflicting results after treating thermal burns with HBOT or TOT. Overall, 14/23 studies demonstrated positive results for HBOT on the healing of burn wounds and associated complications, such as oedema and pain. Findings from these studies showed it can reduce morbidity and mortality in certain high-risk groups such as those with diabetes or extensive burns. Although the five studies (one human and four animal trials) reviewing TOT showed promising outcomes, this therapeutic modality has not been well investigated.
Therapeutic use of HBOT in thermal burns has been popular in the past but its use remains controversial due to inconsistent results, serious side-effects, lack of convenience and high costs. The use of TOT in the management of burns needs further exploration by scientists and clinicians alike, in addition to the implementation of a standardised treatment protocol.
本综述旨在评估两种最常用的氧输送方法治疗热烧伤创面愈合的有效性：高压氧疗法（HBOT）和局部氧疗法（TOT）。
检索PubMed数据库中讨论HBOT或TOT用于治疗热烧伤的文章。
检索得到43406篇文章，其中28篇（23篇关于HBOT，5篇关于TOT）符合纳入标准。实验研究和临床研究均表明，用HBOT或TOT治疗热烧伤后结果相互矛盾。总体而言，14/23的研究表明HBOT对烧伤创面愈合及相关并发症（如水肿和疼痛）有积极效果。这些研究结果表明，它可以降低某些高危人群（如糖尿病患者或大面积烧伤患者）的发病率和死亡率。尽管五项评估TOT的研究（一项人体试验和四项动物试验）显示出有前景的结果，但这种治疗方式尚未得到充分研究。
过去HBOT在热烧伤治疗中的应用很普遍，但由于结果不一致、严重副作用、不便性和高成本，其应用仍存在争议。除了实施标准化治疗方案外，TOT在烧伤治疗中的应用还需要科学家和临床医生进一步探索。
