Center for Tissue Engineering, Plastic Surgery Department, University of California, Irvine, California.
Biomedical Engineering Department, University of California, Irvine, California.
Int Wound J. 2018 Jun;15(3):363-374. doi: 10.1111/iwj.12873. Epub 2018 Jan 5.
Up to 15 billion dollars of US health care expenditure each year is consumed by treatment of poorly healing wounds whose etiologies are often associated with aberrancies in tissue oxygenation. To address this issue, several modes of tissue oxygen delivery systems exist, including Hyperbaric Oxygen Therapy (HBOT) and Topical Oxygen Therapy (TOT), but their efficacies have yet to be fully substantiated. Micro/nanobubbles (MNBs), which range anywhere from 100 μm to <1 μm in diameter and are relatively stable for hours, offer a new mode of oxygen delivery to wounds. The aim of this article is to systematically review literature examining the use of TOT for wound healing and use of MNBs for tissue oxygenation using the MEDLINE database. The search yielded 87 articles (12 MNB articles and 75 TOT articles), of which 52 met the inclusion criteria for this literature review (12 MNB articles and 40 TOT articles). Additionally, we present an analysis on the efficacy of our MNB generating technology and propose its use as a wound healing agent.
每年，高达 150 亿美元的美国医疗保健支出用于治疗愈合不良的伤口，而这些伤口的病因通常与组织氧合异常有关。为了解决这个问题，存在几种组织氧输送系统，包括高压氧治疗（HBOT）和局部氧治疗（TOT），但其疗效尚未得到充分证实。微/纳米气泡（MNBs）的直径范围为 100μm 至<1μm，并且相对稳定数小时，为伤口提供了一种新的供氧方式。本文的目的是使用 MEDLINE 数据库系统地回顾文献，检查 TOT 用于伤口愈合和 MNB 用于组织氧合的用途。该搜索产生了 87 篇文章（12 篇 MNB 文章和 75 篇 TOT 文章），其中 52 篇符合本文献综述的纳入标准（12 篇 MNB 文章和 40 篇 TOT 文章）。此外，我们还对我们的 MNB 生成技术的功效进行了分析，并提出将其用作伤口愈合剂。
