双相情感障碍、重度抑郁症和自杀意念是否与代谢综合征有关？一项血清分子病例对照研究。

Are bipolar disorder, major depression, and suicidality linked with ? A seromolecular case-control study.

机构信息

Department of Psychiatry, Istanbul University - Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Türkiye.

Department of Medical Microbiology, Istanbul Aydin University, Faculty of Medicine, Istanbul, Türkiye.

出版信息

Postgrad Med. 2023 Mar;135(2):179-186. doi: 10.1080/00325481.2023.2176042. Epub 2023 Feb 6.

DOI:10.1080/00325481.2023.2176042

PMID:36724454

Abstract

OBJECTIVE

The existence of predisposing effects of latent () infection in bipolar disorder (BD), major depression (MD), and even suicide attempt (SA) has long been debatable. This conjecture remains unclear because there is a lack of evidence regarding how manipulates the brain and behavior.

METHODS

We investigated the influence of infection on BD and MD patients with or without SA compared to age-, sex-, and province-matched healthy controls (HCs) concurrently with serology and molecular-based evaluations. We prospectively assessed 147 volunteers with BD, 161 with MD, and 310 HCs.

RESULTS

seropositivity rates were 57.1% for BD, 29.2% for MD, 64.8% for SA, and 21.3% for HC. Binary logistic regression analyses revealed that positive Immunoglobulin G (IgG) status may be a prominent tendentious agent for BD (OR = 3.52; 95% CI [2.19-5.80]; p < 0.001) and SA (OR = 17.17; 95% CI [8.12-36.28]; p < 0.001), but not for MD (OR = 1.21; 95% CI [0.74-1.99]; p = 0.45). Nevertheless, the DNA ratios determined by polymerase chain reaction (PCR) were linked to BD and MD.

CONCLUSION

Our findings strongly support the burgeoning interest in the possibility that latent infection may be relevant to the etiology of BD and SA, although this connection remains ambiguous.

摘要

目的

潜伏性感染在双相情感障碍（BD）、重度抑郁症（MD）甚至自杀未遂（SA）中是否存在易患效应，这一观点长期以来一直存在争议。这种推测仍然不清楚，因为缺乏关于如何操纵大脑和行为的证据。

方法

我们同时进行血清学和基于分子的评估，调查了感染对 BD 和 MD 患者（无论是否有 SA）与年龄、性别和省份匹配的健康对照者（HC）的影响。我们前瞻性评估了 147 名 BD 患者、161 名 MD 患者和 310 名 HC。

结果

BD 的血清阳性率为 57.1%，MD 为 29.2%，SA 为 64.8%，HC 为 21.3%。二元逻辑回归分析显示，阳性 IgG 状态可能是 BD（OR=3.52；95%CI[2.19-5.80]；p<0.001）和 SA（OR=17.17；95%CI[8.12-36.28]；p<0.001）的一个突出的倾向因素，但不是 MD（OR=1.21；95%CI[0.74-1.99]；p=0.45）。然而，聚合酶链反应（PCR）确定的 DNA 比值与 BD 和 MD 相关。