Shinbiosis Corp., 106 Kobe Health Industry Development Center.
Intestinal Microbiota Transplantation Clinical Research Inc.
Biol Pharm Bull. 2023;46(2):343-347. doi: 10.1248/bpb.b22-00631.
Owing to their unique physicochemical properties and diverse biological effects, ultrafine bubbles (UFBs) have recently been expected to be utilized for industrial and biological purposes. Thus, this study investigated the biological safety of UFBs in water for living beings in drinking the water with a view to future use in health sciences. In this study, we used H-filled UFBs (NanoGAS) that can hold hydrogen in the aqueous phase for a long time. Mice were randomly assigned to one of three groups: those receiving NanoGAS water, reverse osmosis water, or natural mineral water, and they ingested it ad libitum for one month or three months. As a result, subchronic drinking of NanoGAS water does not affect either the common blood biochemical parameters or the health of the organs and mucosal membranes. Our results, for the first time, scientifically demonstrated the biological safety of H-filled UFBs water for subchronic oral consumption.
由于其独特的物理化学性质和多样的生物学效应，超细微气泡（UFBs）最近有望被应用于工业和生物领域。因此，本研究旨在调查饮用水中超细微气泡（UFBs）对生物的安全性，以期未来在健康科学领域得到应用。在本研究中，我们使用了可以在水相中长时间保持氢气的 H 填充超细微气泡（NanoGAS）。将小鼠随机分为三组：NanoGAS 水组、反渗透水组和天然矿泉水组，它们自由饮用一个月或三个月。结果表明，亚慢性饮用 NanoGAS 水不会影响常见的血液生化参数或器官和粘膜的健康。我们的研究结果首次从科学上证明了 H 填充超细微气泡水用于亚慢性口服摄入的生物安全性。
