Huynh Thanh Hao, Wen Zhi-Hong, Su Jui-Hsin, Yao Zhi-Kang, Zheng Li-Guo, Tsai Yu-Chi, Tanaka Junichi, Liaw Chia-Ching, Sung Ping-Jyun
Department of Marine Biotechnology and Resources, National Sun Yat-sen University.
National Museum of Marine Biology & Aquarium.
Chem Pharm Bull (Tokyo). 2023;71(2):183-187. doi: 10.1248/cpb.c22-00605.
A formerly unpublicized briarane diterpenoid, briastecholide M (1), and its established analogue, brianodin B (2), were purified from Briareum stechei, an octocoral collected from Okinawan waters. Using spectroscopic methods, the structure of 1 was established. Functional study showed that 1 can reducing the release of inducible nitric oxide synthase (iNOS) but enhancing cyclooxygenase-2 (COX-2) protein expression.
从采集自冲绳海域的八放珊瑚软珊瑚中纯化得到一种此前未公开的 briarane 二萜类化合物 briastecholide M（1）及其已知类似物 brianodin B（2）。通过光谱方法确定了 1 的结构。功能研究表明，1 可减少诱导型一氧化氮合酶（iNOS）的释放，但增强环氧合酶 -2（COX-2）蛋白表达。
