Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan.
Molecules. 2021 Nov 13;26(22):6861. doi: 10.3390/molecules26226861.
A known polyoxygenated briarane, briaexcavatolide P (), was isolated from a Formosan octocoral . Moreover, the same species , collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B () and C () as well as a known analogue, briarenol R (). The structures of - were established using spectroscopic methods. In addition, briarane demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.
一种已知的多氧化石珊瑚烷，briaexcavatolide P（），从台湾产的八放珊瑚中分离得到。此外，从冲绳海域采集到的同一物种产生了三种含氯石珊瑚烷，包括两个新化合物，briastecholides B（）和 C（）以及一种已知的类似物，briarenol R（）。-的结构是通过光谱方法确定的。此外，briarane 通过抑制诱导型一氧化氮合酶（iNOS）蛋白的表达，在脂多糖诱导的 RAW 264.7 小鼠巨噬细胞中显示出抗炎活性。
