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对奥马珠单抗的过敏反应：源自对 2019 年冠状病毒疫苗的反应的教训。

Allergy to Omalizumab: Lessons from a Reaction to the Coronavirus 2019 Vaccine.

机构信息

Department of Respiratory Medicine, Saiseikai-Noe Hospital, Japan.

Department of Dermatology, Saiseikai-Noe Hospital, Japan.

出版信息

Intern Med. 2023 Apr 15;62(8):1219-1222. doi: 10.2169/internalmedicine.1169-22. Epub 2023 Feb 1.

DOI:10.2169/internalmedicine.1169-22
PMID:36725035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10183271/
Abstract

Omalizumab can cause hypersensitivity reactions. We herein report the first case of an 18-year-old woman with refractory cough-predominant asthma that correlated with allergic reactions caused by omalizumab and the coronavirus disease 2019 (COVID-19) vaccine. The patient developed angioedema after taking omalizumab. She had previously experienced intense coughing immediately after receiving a COVID-19 vaccine. A skin prick test was positive for polysorbate 20, which was probably the cause of the allergic reactions to omalizumab and the COVID-19 vaccine. Clinicians should check for an allergic reaction, irrespective of its intensity, triggered by polysorbate and be careful when prescribing biologics to patients in order to avoid allergic reactions.

摘要

奥马珠单抗可引起过敏反应。本研究报告了首例与奥马珠单抗和新型冠状病毒病（COVID-19）疫苗相关的、以咳嗽为主要表现的难治性哮喘的 18 岁女性病例。该患者在使用奥马珠单抗后出现血管性水肿。她之前在接种 COVID-19 疫苗后立即出现剧烈咳嗽。皮肤点刺试验对聚山梨酯 20 呈阳性，这可能是奥马珠单抗和 COVID-19 疫苗过敏反应的原因。临床医生应检查由聚山梨酯引起的过敏反应，无论其严重程度如何，并在为患者开生物制剂时要小心，以避免过敏反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/10183271/be6e50759c1d/1349-7235-62-1219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/10183271/be6e50759c1d/1349-7235-62-1219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/10183271/be6e50759c1d/1349-7235-62-1219-g001.jpg

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本文引用的文献

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2
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J Allergy Clin Immunol Pract. 2022 Mar;10(3):859-862. doi: 10.1016/j.jaip.2021.12.025. Epub 2022 Jan 1.
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