Department of Rehabilitation, Hamamatsu Medical Center, Japan.
School of Rehabilitation Science, Seirei Christopher University, Japan.
Intern Med. 2023 Sep 15;62(18):2643-2650. doi: 10.2169/internalmedicine.0871-22. Epub 2023 Feb 1.
Objective The treatment background, as well as the frequency and type of complications, in autologous (auto-) and allogeneic (allo-) hematopoietic stem cell transplantation (HSCT) survivors influence the appearance of moderate to vigorous physical activity (MVPA) or sedentary behavior. We therefore assessed differences in the MVPA and sedentary behavior between auto- and allo-HSCT survivors. Methods This prospective observational study included 13 auto- and 36 allo-HSCT survivors (approximately 4 years after HSCT). The MVPA and sedentary behavior were assessed using a triaxial accelerometer. Results There were no significant between-group differences in the MVPA or sedentary behavior (p=0.768 and 0.739, respectively). In allo-HSCT survivors, the MVPA was negatively correlated with the Hospital Anxiety and Depression Scale score (r=-0.358, p=0.032). A stepwise multiple regression analysis showed that age was a significant predictor of sedentary behavior in allo-HSCT survivors (β=0.400, p=0.016). Conclusion We observed no significant between-group differences in the MVPA or sedentary behavior. Our results suggest that it may be unnecessary to change the rehabilitation program according to the donor type in interventions for promoting MVPA and reducing sedentary behavior in long-term HSCT survivors.
目的
自体（auto-）和异基因（allo-）造血干细胞移植（HSCT）幸存者的治疗背景、并发症的频率和类型会影响中度至剧烈体力活动（MVPA）或久坐行为的出现。因此，我们评估了自体和异基因 HSCT 幸存者之间 MVPA 和久坐行为的差异。
方法
本前瞻性观察研究纳入了 13 名自体和 36 名异基因 HSCT 幸存者（大约在 HSCT 后 4 年）。使用三轴加速度计评估 MVPA 和久坐行为。
结果
MVPA 或久坐行为在两组间无显著差异（p=0.768 和 0.739）。在异基因 HSCT 幸存者中，MVPA 与医院焦虑抑郁量表评分呈负相关（r=-0.358，p=0.032）。逐步多元回归分析显示，年龄是异基因 HSCT 幸存者久坐行为的显著预测因子（β=0.400，p=0.016）。
结论
我们观察到 MVPA 或久坐行为在两组间无显著差异。我们的结果表明，在促进长期 HSCT 幸存者的 MVPA 和减少久坐行为的干预措施中，可能无需根据供体类型改变康复方案。
