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多发转移性胃肠道外间质瘤伴浆细胞样分化:病例报告及文献复习。

Multiple Metastatic Extra-gastrointestinal Stromal Tumors with Plasmoid Differentiation: A Case Report and Review of Literature.

机构信息

Department of Pathology, the Third Affiliated Hospital of Kunming Medical University, China.

Department of Imaging, the Third Affiliated Hospital of Kunming Medical University, China.

出版信息

Intern Med. 2023;62(3):393-398. doi: 10.2169/internalmedicine.9727-22. Epub 2023 Feb 1.

DOI:10.2169/internalmedicine.9727-22
PMID:36725066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9970808/
Abstract

Extra-gastrointestinal stromal tumors (EGISTs) are rare mesenchymal tumors that arise from the abdominal, pelvic or retroperitoneal region, unrelated to the gastrointestinal tract. However, cases with a plasmoid morphology are extremely rare. we hererin report a 49-year-old man with abdominal pain who underwent magnetic resonance imaging that revealed an irregular tumor (103×71 mm) in size, in the space between stomach and pancreas, diagnosed as an EGISIT, we also reviewed the clinicopathological characteristics and immunohistochemical characteristics, molecular genetic features and differential diagnoses previously reported in the literature.

摘要

胃肠道外间质瘤(EGISTs)是一种罕见的间叶源性肿瘤,起源于腹部、盆腔或腹膜后区域,与胃肠道无关。然而,具有浆细胞样形态的病例极为罕见。在此,我们报告一例 49 岁男性,因腹痛就诊,行磁共振成像检查发现胃和胰腺之间有一大小为 103×71mm 的不规则肿瘤,诊断为 EGIST。我们还复习了文献中既往报道的该肿瘤的临床病理特征、免疫组织化学特征、分子遗传学特征和鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/940b8e35aa3a/1349-7235-62-0393-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/3bae5862e8d5/1349-7235-62-0393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/968eaeb62a61/1349-7235-62-0393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/ce2ddee25f8a/1349-7235-62-0393-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/940b8e35aa3a/1349-7235-62-0393-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/3bae5862e8d5/1349-7235-62-0393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/968eaeb62a61/1349-7235-62-0393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/ce2ddee25f8a/1349-7235-62-0393-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f13/9970808/940b8e35aa3a/1349-7235-62-0393-g004.jpg

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Ann Med Surg (Lond). 2022 Jan 25;74:103283. doi: 10.1016/j.amsu.2022.103283. eCollection 2022 Feb.
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Mol Clin Oncol. 2021 Dec;15(6):249. doi: 10.3892/mco.2021.2411. Epub 2021 Oct 1.
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Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up.
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Ann Oncol. 2022 Jan;33(1):20-33. doi: 10.1016/j.annonc.2021.09.005. Epub 2021 Sep 21.
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