Chang Cen, Zhang Run-Run, Shi Yi-Ming, He Dong-Yi
Department of Arthritis, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine Shanghai 200052, China Arthritis Institute of Integrative Medicine, Shanghai Institute of Integrative Medicine Shanghai 200052, China Shanghai University of Traditional Chinese Medicine Shanghai 200052, China.
the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine Ji'nan 250002, China.
Zhongguo Zhong Yao Za Zhi. 2023 Jan;48(2):329-335. doi: 10.19540/j.cnki.cjcmm.20220922.502.
Rheumatoid arthritis(RA) is an autoimmune disease that seriously affects the physical and mental health of patients, but its pathogenesis is still unclear. At present, clinical treatment drugs include conventional synthetic disease modifing anti-rheumatic drugs(csDMARDs), nonsteroid anti-inflammtory drugs(NSAIDs), hormones, small molecule targeted drugs, biological agents, etc. These drugs can relieve the clinical symptoms of most patients with RA to a certain extent, but there are still many limitations, such as drug adverse reactions and individual differences in drug efficacy. Therefore, the research on drug treatment targets and the development of low-toxicity drugs helps further improve the precise prevention, diagnosis, and treatment of RA. There is an urgent need for efficient and low-toxic treatments to delay the clinical progress of RA. As a treasure of Chinese culture, traditional Chinese medicine(TCM) is widely used as an alternative therapy in the treatment of various diseases, and has a significant clinical efficacy. TCM therapy(including monomer traditional Chinese medicine, classical compounds, and non-drug therapies) has a significant curative effect on RA. Based on the literature research in recent years, this paper reviewed the clinical and mechanism research of TCM therapy in the treatment of RA, and provided more in-depth thinking for the wide application of TCM therapy in clinical practice.
类风湿关节炎（RA）是一种严重影响患者身心健康的自身免疫性疾病，但其发病机制仍不清楚。目前，临床治疗药物包括传统合成改善病情抗风湿药（csDMARDs）、非甾体抗炎药（NSAIDs）、激素、小分子靶向药物、生物制剂等。这些药物能在一定程度上缓解大多数RA患者的临床症状，但仍存在诸多局限性，如药物不良反应和药物疗效的个体差异等。因此，对药物治疗靶点的研究以及低毒药物的开发有助于进一步提高RA的精准预防、诊断和治疗水平。迫切需要高效低毒的治疗方法来延缓RA的临床进展。作为中华文化瑰宝，传统中医药（TCM）在各种疾病的治疗中被广泛用作替代疗法，且具有显著的临床疗效。中医治疗（包括单味中药、经典复方及非药物疗法）对RA具有显著疗效。基于近年来的文献研究，本文综述了中医治疗RA的临床及机制研究，为中医治疗在临床实践中的广泛应用提供了更深入的思考。
