Lateral Preoptic Hypothalamus: A Window to Understanding Insomnia.
作者信息
Taksokhan Anita, Kim Kyungwook
机构信息
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G3, Canada.
出版信息
J Neurosci. 2023 Feb 1;43(5):682-684. doi: 10.1523/JNEUROSCI.1560-22.2022.
Abstract
摘要
相似文献
1
Lateral Preoptic Hypothalamus: A Window to Understanding Insomnia.外侧视前区下丘脑：理解失眠的一扇窗口。
J Neurosci. 2023 Feb 1;43(5):682-684. doi: 10.1523/JNEUROSCI.1560-22.2022.
2
NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep.外侧视前下丘脑的 NMDA 受体对于维持非快速动眼睡眠和快速动眼睡眠是必需的。
J Neurosci. 2022 Jul 6;42(27):5389-5409. doi: 10.1523/JNEUROSCI.0350-21.2022. Epub 2022 Jun 1.
3
Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat.视前神经元损伤诱发猫的长期失眠及其通过向下丘脑后部注射蝇蕈醇实现短暂逆转。
Neuroscience. 1989;32(3):669-83. doi: 10.1016/0306-4522(89)90289-3.
4
Hypothalamic control of sleep.下丘脑对睡眠的控制。
Sleep Med. 2007 Jun;8(4):291-301. doi: 10.1016/j.sleep.2007.03.013. Epub 2007 Apr 30.
5
Glutamatergic Neurons in the Preoptic Hypothalamus Promote Wakefulness, Destabilize NREM Sleep, Suppress REM Sleep, and Regulate Cortical Dynamics.下丘脑视前区的谷氨酸能神经元促进觉醒，破坏非快速眼动睡眠，抑制快速眼动睡眠，并调节皮质动力学。
J Neurosci. 2021 Apr 14;41(15):3462-3478. doi: 10.1523/JNEUROSCI.2718-20.2021. Epub 2021 Mar 4.
6
Administration of the protein synthesis inhibitor, anisomycin, has distinct sleep-promoting effects in lateral preoptic and perifornical hypothalamic sites in rats.给予蛋白质合成抑制剂茴香霉素，对大鼠视前外侧和下丘脑穹窿周部位具有明显的促睡眠作用。
Neuroscience. 2008 Jan 2;151(1):1-11. doi: 10.1016/j.neuroscience.2007.09.051. Epub 2007 Sep 29.
7
8
Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons.单胺类神经递质抑制腹外侧视前区 GABA 能神经元，这些神经元与下丘脑觉醒神经元形成直接突触连接。
J Neurosci. 2018 Jul 11;38(28):6366-6378. doi: 10.1523/JNEUROSCI.2835-17.2018. Epub 2018 Jun 18.
9
Preoptic area warming inhibits wake-active neurons in the perifornical lateral hypothalamus.视前区升温会抑制穹窿周外侧下丘脑的觉醒活跃神经元。
Brain Res. 2003 Jan 17;960(1-2):165-73. doi: 10.1016/s0006-8993(02)03808-8.
10
REM sleep stabilizes hypothalamic representation of feeding behavior.快速眼动睡眠稳定了摄食行为的下丘脑表现。
Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19590-19598. doi: 10.1073/pnas.1921909117. Epub 2020 Jul 30.
引用本文的文献
1
Exploratory GABAa-informed control network modulates hyperarousal brain dynamics in chronic insomnia.探索性γ-氨基丁酸A受体（GABAa）信息控制网络调节慢性失眠中的过度觉醒脑动力学。
Commun Biol. 2025 Jul 3;8(1):991. doi: 10.1038/s42003-025-08439-4.
2
Temporal Feature Extraction and Machine Learning for Classification of Sleep Stages Using Telemetry Polysomnography.使用遥测多导睡眠图进行睡眠阶段分类的时间特征提取与机器学习
Brain Sci. 2023 Aug 14;13(8):1201. doi: 10.3390/brainsci13081201.
本文引用的文献
1
Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area.腹外侧延髓谷氨酸能神经元投射至视前区对非快速眼动睡眠的控制。
Nat Commun. 2022 Aug 12;13(1):4748. doi: 10.1038/s41467-022-32461-3.
2
NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep.外侧视前下丘脑的 NMDA 受体对于维持非快速动眼睡眠和快速动眼睡眠是必需的。
J Neurosci. 2022 Jul 6;42(27):5389-5409. doi: 10.1523/JNEUROSCI.0350-21.2022. Epub 2022 Jun 1.
3
Glutamatergic Neurons in the Preoptic Hypothalamus Promote Wakefulness, Destabilize NREM Sleep, Suppress REM Sleep, and Regulate Cortical Dynamics.下丘脑视前区的谷氨酸能神经元促进觉醒，破坏非快速眼动睡眠，抑制快速眼动睡眠，并调节皮质动力学。
J Neurosci. 2021 Apr 14;41(15):3462-3478. doi: 10.1523/JNEUROSCI.2718-20.2021. Epub 2021 Mar 4.
4
Acute blockade of NR2C/D subunit-containing N-methyl-D-aspartate receptors modifies sleep and neural oscillations in mice.
J Sleep Res. 2021 Aug;30(4):e13257. doi: 10.1111/jsr.13257. Epub 2020 Dec 13.
5
The Lateral Preoptic Area and Its Projection to the VTA Regulate VTA Activity and Drive Complex Reward Behaviors.外侧视前区及其向腹侧被盖区的投射调节腹侧被盖区的活动并驱动复杂的奖赏行为。
Front Syst Neurosci. 2020 Nov 3;14:581830. doi: 10.3389/fnsys.2020.581830. eCollection 2020.
6
NMDAR activation regulates the daily rhythms of sleep and mood.NMDAR 激活调节睡眠和情绪的昼夜节律。
Sleep. 2019 Oct 9;42(10). doi: 10.1093/sleep/zsz135.
7
An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control.中脑 perioculomotor 中的兴奋性回路用于非快速动眼睡眠控制。
Cell. 2019 May 16;177(5):1293-1307.e16. doi: 10.1016/j.cell.2019.03.041. Epub 2019 Apr 25.
8
GABA and glutamate neurons in the VTA regulate sleep and wakefulness.腹侧被盖区的 GABA 和谷氨酸能神经元调节睡眠和觉醒。
Nat Neurosci. 2019 Jan;22(1):106-119. doi: 10.1038/s41593-018-0288-9. Epub 2018 Dec 17.
9
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice.室旁核内的甘丙肽神经元促进小鼠睡眠和散热。
Nat Commun. 2018 Oct 8;9(1):4129. doi: 10.1038/s41467-018-06590-7.
10
Short- and long-term health consequences of sleep disruption.睡眠中断的短期和长期健康后果。
Nat Sci Sleep. 2017 May 19;9:151-161. doi: 10.2147/NSS.S134864. eCollection 2017.
Zotero 插件