Xu Xinlin, Gacek Serena, Cai Jie, Lin Fusheng, Ma Chao, Zhuang Peiyun
Department of Voice, School of Medicine, Key Laboratory of Voice of Xiamen City, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, China.
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
J Voice. 2025 Jul;39(4):996-1002. doi: 10.1016/j.jvoice.2023.01.010. Epub 2023 Jan 30.
To explore the glycolytic metabolism of contralateral vocal fold compensation by examining the glycolytic metabolism of the posterior region of vocal folds in beagles with unilateral vocal fold immobility disorders and its correlation with acoustic parameters.
Prospective animal study.
Department of Voice METHODS: Ten adult beagles were divided randomly into three groups: a unilateral cricoarytenoid joint dislocation (UCAJD) group (n = 4), a unilateral vocal fold paralysis (UVFP) group (n = 4), and a control group (n = 2). Positron emission tomography-computed tomography (PET/CT) scans of larynx and recordings of vocalizations were collected 4 months after the operations. The maximum standardized uptake values (SUVmax) of 18F-FDG within each posterior region of the vocal folds were obtained from PET/CT and voice recordings were analyzed for acoustic parameters F0, jitter, shimmer, and loudness using PRAAT.
In both UCAJD and UVFP groups, a significant increase of SUVmax was observed in the contralateral vocal fold relative to the impaired fold (P < 0.05). The SUVmax values of the contralateral vocal folds and the SUVmax values of the impaired vocal folds in the UCAJD, UVFP, and control groups were both found to be significantly different (P < 0.05). The SUVmax of the contralateral vocal fold may exhibit a potentially negative correlation with jitter and shimmer, with R2 values of 0.42 and 0.26 and P values of 0.03 and 0.11, respectively.
UCAJD and UVFP can cause enhanced glycolytic metabolism of the contralateral vocal fold relative to the impaired vocal fold. The SUVmax of the contralateral vocal fold may be positively correlated with acoustic quality.
通过检测单侧声带运动障碍比格犬声带后部的糖酵解代谢及其与声学参数的相关性，探讨对侧声带代偿的糖酵解代谢情况。
前瞻性动物研究。
嗓音科
将10只成年比格犬随机分为三组：单侧环杓关节脱位（UCAJD）组（n = 4）、单侧声带麻痹（UVFP）组（n = 4）和对照组（n = 2）。术后4个月收集喉部正电子发射断层扫描-计算机断层扫描（PET/CT）图像和发声记录。从PET/CT中获取声带各后部区域内18F-FDG的最大标准化摄取值（SUVmax），并使用PRAAT分析发声记录的声学参数F0、抖动率、闪烁率和响度。
在UCAJD组和UVFP组中，相对于受损声带，对侧声带的SUVmax均显著增加（P < 0.05）。发现UCAJD组、UVFP组和对照组中对侧声带的SUVmax值与受损声带的SUVmax值均有显著差异（P < 0.05）。对侧声带的SUVmax可能与抖动率和闪烁率呈潜在负相关，R2值分别为0.42和0.26，P值分别为0.03和0.11。
UCAJD和UVFP可导致对侧声带相对于受损声带的糖酵解代谢增强。对侧声带的SUVmax可能与声学质量呈正相关。
