J Am Pharm Assoc (2003). 2023 May-Jun;63(3):785-792. doi: 10.1016/j.japh.2023.01.004. Epub 2023 Jan 10.
Prescription medication labels are often constructed in a manner which hinders safe and appropriate use of medicines. The United States Pharmacopeia released voluntary standards to revise medication labels in an effort to support patients' understanding and improve medication use.
To examine the impact of label changes on medication adherence before and after pharmacy implementation of the United States Pharmacopeia patient-centered prescription medication label standards.
This study used a retrospective pre-post cohort design. Prescription fill claims data were obtained from a community health plan serving Medicaid patients for 1 independent community pharmacy organization across 8 retail pharmacy sites. We calculated medication possession ratios (MPR) and proportion of days covered (PDC) for medications used for contraception, asthma, hypertension, and depression from 15 months before to 13 months after implementation of the label changes.
Findings showed significant increases in mean MPR for asthma controller (increased by 0.111 [t = 0.290, P<0.0001]), antihypertensives (increased by 0.062 [t = 0.146, P < 0.0002]), and contraceptives medications (increased 0.133 [t = 0.209, P < 0.0001]) from preintervention to postintervention periods. Results also revealed increases in mean PDC for asthma controllers (increased by 0.193 [t = 0.267, P < 0.0001]), antihypertensives (increased by 0.067 [t = 0.175, P = 0.049]), and contraceptives (increased by 0.111 [t = 0.208, P < 0.0119]) from preintervention to postintervention periods.
We report an association between a change to more patient-centered prescription medication labels and increased medication adherence based on MPR and PDC among Medicaid recipients.
处方药标签的设计方式常常会妨碍患者安全、合理地使用药物。为了帮助患者理解并改善用药，美国药典会发布了自愿标准以修订用药标签。
考察药剂实施美国药典会以患者为中心的处方药标签标准前后，标签变更对用药依从性的影响。
本研究采用回顾性前后群组设计。从一家为医疗补助计划患者服务的社区医疗计划中获取了一家独立社区药房组织在 8 家零售药房的处方配药数据。我们计算了标签变更前后 15 个月至 13 个月期间用于避孕、哮喘、高血压和抑郁症的药物的用药持续率（MPR）和用药天数比例（PDC）。
研究结果显示，哮喘控制药物（增加 0.111，t=0.290，P<0.0001）、降压药物（增加 0.062，t=0.146，P<0.0002）和避孕药（增加 0.133，t=0.209，P<0.0001）的 MPR 均值显著增加。研究结果还表明，哮喘控制药物（增加 0.193，t=0.267，P<0.0001）、降压药物（增加 0.067，t=0.175，P=0.049）和避孕药（增加 0.111，t=0.208，P<0.0119）的 PDC 均值均增加。
我们报告了更以患者为中心的处方药标签变更与医疗补助受助人的 MPR 和 PDC 用药依从性增加之间存在关联。
