Yoshii F, Saitoh H, Takizawa S, Shinohara Y
Department of Neurology, School of Medicine, Tokai University, Japan.
Tokai J Exp Clin Med. 1986 Nov;11(5):361-9.
A contribution of cerebral cortical damage to the development of intellectual impairment in patients with Parkinson's disease (PD) has been suspected. We studied the relationship between intellectual impairment and cerebral cortical blood flow in 28 treated idiopathic parkinsonian patients. Mean IQ score as evaluated by applying the Suzuki-Binet test in patients with PD was 70.7 (+/- 12.7) and 78.6% of the patients showed abnormal score (below 80). The intellectual deficits were characterized by impairment of memory and abstract thinking, and showed a significant correlation with the severity of motor symptoms. Mean hemispheric cortical blood flow measured by using the 133xenon intravenous injection technique in patients with PD was significantly lower than that for 18 age-matched controls. Prefrontal cortical blood flow in PD was also significantly reduced compared with that in age-matched controls, showing a partial loss of hyperfrontal pattern. However, there was no significant correlation between IQ score and either mean hemispheric cortical blood flow or prefrontal cortical blood flow values. These results suggest that, although the patients with PD demonstrated a high prevalence of intellectual impairment, the impairment is not necessarily of cortical origin.
人们怀疑帕金森病（PD）患者的智力损害发展与大脑皮质损伤有关。我们研究了28例接受治疗的特发性帕金森病患者智力损害与大脑皮质血流之间的关系。应用铃木 - 比奈测试评估，PD患者的平均智商得分为70.7（±12.7），78.6%的患者得分异常（低于80）。智力缺陷的特征是记忆和抽象思维受损，并且与运动症状的严重程度显著相关。使用133氙静脉注射技术测量，PD患者的平均半球皮质血流显著低于18名年龄匹配的对照组。与年龄匹配的对照组相比，PD患者的前额叶皮质血流也显著降低，呈现出部分额叶活动增强模式的丧失。然而，智商得分与平均半球皮质血流或前额叶皮质血流值之间均无显著相关性。这些结果表明，尽管PD患者智力损害的患病率较高，但这种损害不一定源于皮质。
