Matsuda H, Maeda T, Yamada M, Gui L X, Hisada K
No To Shinkei. 1982 Nov;34(11):1091-7.
In order to investigate an influence of advancing age on regional cerebral blood flow, 125 measurements of rCBF were made by 133Xe inhalation method in 90 normal subjects without cerebral symptoms and risk factors of atherothrombotic stroke including hypertension, diabetes mellitus, and hyperlipidemia. There were 46 male and 44 female aged 19 to 80 years old (mean 42.5). The measurements were carried out in a quiet, semi-darkened room with the subjects at rest and eye closed. 133Xe inhalation system (Meditronic-Novo Diagnostic Systems, Inhalation Cerebrograph, Denmark) consists of 32 scintillation detectors, the lateral part of each hemisphere being covered by 16 detectors placed in parallel. One pair of the detectors is mounted in place over the brain stem and cerebellar region. Relationship of age and rCBF computed as the initial slope index (ISI) by Fourier analysis was investigated with both correlation and regression analyses, and age-matched normal values were calculated. End-tidal partial pressure for carbon dioxide (PECO2) was recorded from the face mask during the measurements along with the mean arterial blood pressure (MABP). ISI values were not corrected for changes in PECO2. PECO2 and MABP did not differ significantly among the normal subjects. There were no significant differences in the hemispheric mean ISI values between the right and left hemispheres. Mean brain ISI values showed significant negative correlation with advancing age (r = -0.67, p less than 0.001), and regression line was Y = -0.30X + 67.8. Ninety five per-cent confidence interval of the regression line was +/- 11.8. Regional ISI values also showed significant negative correlations with advancing age in the whole brain (p less than 0.001). There were no significant differences in the correlation coefficients obtained from parallel regions between the right and left hemispheres. The regional reduction of ISI values with advancing age was significantly greater in the regional distribution of the middle cerebral arteries bilaterally, compared with regions in the distribution of either the anterior cerebral, the posterior cerebral, or vertebrobasilar arteries (p less than 0.05). Regional hemispheric percent value of frontal lobe was greater than that of either parietal, temporal, occipital lobe, or brain stem and cerebellar region in the whole age. But, this hyperfrontal distribution became gradually obscured with advancing age, because reduction of ISI values with aging was significantly greater in the frontal than in other regions. It is concluded that measured rCBF of a patient have to be compared with age-matched normal values of mean brain and each region. Judgment image was produced with dividing patient value by 95% confidence limit of age-matched normal value. According to this image, regions in which rCBF significantly decrease or increase can be easily evaluated.
为了研究增龄对局部脑血流（rCBF）的影响，采用吸入133Xe法对90例无脑部症状且无动脉粥样硬化性血栓形成性卒中危险因素（包括高血压、糖尿病和高脂血症）的正常受试者进行了125次rCBF测量。受试者年龄在19至80岁之间，共46例男性和44例女性（平均42.5岁）。测量在安静、半暗的房间中进行，受试者休息并闭眼。133Xe吸入系统（美敦力-诺和诊断系统公司，丹麦吸入式脑血流图仪）由32个闪烁探测器组成，每个半球的外侧部分由16个平行放置的探测器覆盖。一对探测器安装在脑干和小脑区域上方。通过傅里叶分析计算出初始斜率指数（ISI），并采用相关性和回归分析研究年龄与rCBF的关系，同时计算年龄匹配的正常值。测量过程中，通过面罩记录呼气末二氧化碳分压（PECO2）以及平均动脉血压（MABP）。ISI值未针对PECO2的变化进行校正。正常受试者的PECO2和MABP无显著差异。左右半球的半球平均ISI值无显著差异。平均脑ISI值与增龄呈显著负相关（r = -0.67，p < 0.001），回归线为Y = -0.30X + 67.8。回归线的95%置信区间为±11.8。全脑的局部ISI值也与增龄呈显著负相关（p < 0.001）。左右半球平行区域的相关系数无显著差异。与大脑前动脉、大脑后动脉或椎基底动脉分布区域相比，双侧大脑中动脉分布区域的ISI值随增龄的局部降低更为显著（p < 0.05）。在整个年龄段，额叶的局部半球百分比值高于顶叶、颞叶、枕叶或脑干及小脑区域。但是，随着年龄增长，这种额叶优势分布逐渐不明显，因为额叶ISI值随年龄增长的降低幅度明显大于其他区域。结论是，必须将患者测量的rCBF与年龄匹配的全脑及各区域正常值进行比较。通过将患者值除以年龄匹配正常值的95%置信限生成判断图像。根据该图像，可以轻松评估rCBF显著降低或升高的区域。
